Frequency of Glomerular Dysfunction in Children with Beta Thalassaemia Major

Journal Title: Sultan Qaboos University Medical Journal - Year 2014, Vol 14, Issue 1

Abstract

Objectives: Tis study investigated the frequency of glomerular dysfunction in children with beta thalassaemia major (β-TM) by using different markers and correlating them with serum ferritin and iron chelation therapy. Methods: Te study, carried out between August 2011 and May 2012, included 100 patients with β-TM, in two groups. Group Ia (n = 62) received chelation therapy (deferoxamine). Group Ib (n = 38) received followup care at the Pediatric Hematology Outpatient Clinic, Minia University Children’s Hospital, Egypt. Group II included 50 apparently healthy controls, age- and sex-matched to Group I. All patients underwent a thorough history-taking, clinical examination and laboratory investigations. Results: Compared to Group II, Groups Ia and Ib had signifcantly higher levels of cystatin C, serum creatinine and serum ferritin, and a higher albumin/ creatinine ratio in their urine, and a signifcantly lower estimated glomerular fltration rate (eGFR) and creatinine clearance (P <0.05). Moreover, Group Ιa had a signifcantly lower eGFR and creatinine clearance than Group Ib. Cystatin C had a highly signifcant strong negative correlation with eGFR and creatinine clearance and a signifcantly strong positive correlation with serum ferritin, and a higher sensitivity and specifcity than serum creatinine and creatinine clearance for small changes in GFR. Conclusion: β-TM patients had a high frequency of glomerular dysfunction—possibly attributable to chronic anaemia, iron overload or chelation therapy. Periodic renal assessment is mandatory to detect renal complications. Cystatin C is a promising marker to monitor glomerular dysfunction, having a higher sensitivity and specifcity than serum creatinine and creatinine clearance for small changes in GFR.

Authors and Affiliations

Basma A. Ali| Department of Pediatrics, University Children Hospital, Minia University, Minia, Egypt, Ahmed M. Mahmoud| Department of Pediatrics, University Children Hospital, Minia University, Minia, Egypt

Keywords

Related Articles

VIPoma Crisis Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide

We report the case of a 57-year-old male physician who presented with a life threatening secretory and refractory diarrhoea of around 20 L/day. Tis was complicated by severe hypotension, hypokalaemia, hypercalcaemia, r...

Determination of an Aspergillus fumigatus-Specific Immunoglobulin G Reference Range in an Adult Omani Population

Objectives: The presence of abnormally high levels of Aspergillus fumigatus-specific immunoglobulin (Ig) G antibodies can serve as a diagnostic criterion for severe conditions like allergic bronchopulmonary and chronic...

Impact of Home-to-Centre Distance on Bone Marrow Transplantation Outcomes

Objectives: Haematopoietic stem cell transplantation (HSCT) in Oman started in 1994 at Sultan Qaboos University Hospital (SQUH), Muscat, Oman. Previous studies have suggested that longer driving time to the transplant ce...

Download PDF file
  • EP ID EP14428
  • DOI -
  • Views 325
  • Downloads 9

How To Cite

Basma A. Ali, Ahmed M. Mahmoud (2014). Frequency of Glomerular Dysfunction in Children with Beta Thalassaemia Major. Sultan Qaboos University Medical Journal, 14(1), 88-94. https://europub.co.uk/articles/-A-14428