VIPoma Crisis Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide
Journal Title: Sultan Qaboos University Medical Journal - Year 2011, Vol 11, Issue 1
Abstract
We report the case of a 57-year-old male physician who presented with a life threatening secretory and refractory diarrhoea of around 20 L/day. Tis was complicated by severe hypotension, hypokalaemia, hypercalcaemia, renal failure requiring dialysis, metabolic acidosis, cardiorespiratory arrest and ventilation for 12 days. His diarrhoea responded immediately to the frst dose of a therapeutic trial of subcutaneous octreotide 100 mcg 8 hourly which was started on clinical grounds alone before any investigations were carried out. After one day he was extubated and his blood pressure returned to normal. When a functioning neuroendocrine tumour is suspected clinically, the use of octreotide can, as in this case, be life saving.
Authors and Affiliations
Omayma ElShafe| Departments of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Christopher Grant| Departments of Surgerye, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Aisha Al-Hamdani| Departments of Pathology Sultan Qaboos University Hospital, Muscat, Oman, Rajeev Jain| Departments of Radiology & Molecular Imaging, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Nicholas Woodhouse| Departments Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman
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