Thymic proliferativeresponseduring different physiologicalstates: a comparative study
Journal Title: Sultan Qaboos University Medical Journal - Year 2000, Vol 2, Issue 1
Abstract
–To study the thymic proliferative response during different physiological states to distinguish those changes due to alterations in steroid hormone secretion from those resulting from the presence of spermatozoa and/or early conceptual products in the female reproductive tract. Using mature female rats of an inbred AO(RT1u) strain, observations on the thymus were made at 24 hour intervals during the oestrous cycle, early pseudopregnancy and early syngeneic pregnancy. Each daily group contained a minimum of 6 animals. – During the oestrous cycle, a significant mid-cycle increase of thymocyte proliferation occurred during dioestrus which peaked on day 2, and as a repetitive response may be a preparation for a coital challenge. This response may be oestrogen-dependent since oestrogen levels begin to increase during early dioestrus. The induction of pseudopregnancy generates a comparable but delayed increase in thymic proliferative activity. Since thymocyte proliferation and oestrogen secretion both peak on day 3 of pseudopregnancy, such a response may indeed also be oestrogen-dependent. After syngeneic mating, there was a significant depression in thymic proliferative activity on day 3 followed by a significant increase on day 5 compared with the same days of pseudopregnancy. – This initial depression of proliferative activity may be induced by the immunosuppressive action of seminal plasma, to safeguard the preimplantation conceptus while the day 5 increase in cellular proliferation suggests a response to implantation.
Authors and Affiliations
Habbal O A| Department of Anatomy, College of Medicine, Sultan Qaboos University, P.O.Box: 35, Postal Code: 123, Muscat, Sultanate of Oman, McLean I M| Department of Cell and Structural Biology, Division of Anatomy, Medical School, University of Manchester, Manchester, U.K., Abu-Hijleh M F| Department of Anatomy, Faculty of Medicine, Jordan University of Science & Technology, Irbid, Jordan
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