Frequency of Hepatitis Delta Virus in Hepatitis B Surfaceantigen-positive Patients
Journal Title: Viral Hepatitis Journal - Year 2019, Vol 25, Issue 1
Abstract
Objectives: The prevalence of hepatitis delta virus (HDV) worldwide shows geographical differences. Although there are several studies on anti-HDV seroprevalence rates in hepatitis B surface antigen (HBsAg)-positive patients in Turkey, studies on HDV-RNA prevalence in this patient population are limited. It was aimed to detect the frequency of anti-HDV antibodies and HDV-RNA in HBsAg-positive patients in this study. Materials and Methods: This retrospective study included 2089 HBsAg-positive patients in whom anti-HDV was analyzed between April 2015 and March 2017. Anti-HDV test was performed in serum samples obtained from HBsAg-positive patients by enzyme-linked immunosorbent assay. In anti-HDV-positive patients, HDV-RNA was analyzed in serum samples by real-time polymerase chain reaction. Results: The seroprevalence of anti-HDV was 4.1% (85/2089), while the rate of HDV-RNA positivity was 2.4% (51/2089). HDV-RNA was detected in 60% (51/85) of anti-HDV-positive patients. The frequency of anti-HDV and HDV-RNA was highest in the 50-59 age group. Conclusion: The frequency of HDV in this study was found to be consistent with regional data. HDV viremia was detected in only 60% (51/85) of the anti-HDV-positive patients. Since anti-HDV antibodies may remain after recovery, it is important to investigate HDV-RNA to determine the true prevalence of HDV.
Authors and Affiliations
Ayfer Yolcu, Nuran Karabulut, Sema Alaçam, Mustafa Önel, Melek Büyük, Mine Güllüoğlu, Ali Ağaçfidan
Keywords
Related Articles
- EP ID EP684564
- DOI 10.4274/vhd.galenos.2018-0018
- Views 147
- Downloads 0
Comparison of Qiagen and Iontek Hepatitis B Virus-DNA Polymerase Chain Reaction Quantitation Kits in Chronic Hepatitis B Patients Infected with Hepatitis B Virus Genotype D
Objectives: Hepatitis B virus (HBV)-DNA level is a good marker for viral replication and should be monitored at regular intervals in patients with chronic hepatitis B (CHB). The objective of this study is to compare the...
The Evaluation of the Relation Between Drug Compliance and Psychometric Tests in Chronic B Hepatitis Patients Who are Treated with Oral Antivirals
Objectives: Hepatitis B is a viral infection that causes acute and chronic hepatitis and serious complications such as cirrhosis and hepatocellular cancer. Several psychiatric symptoms and depression, particularly anxiet...
Seroprevalence of HBsAg and Anti-HCV among HIV Positive Patients
Objectives: The study aimed to investigate the seroprevalence of hepatitis B surface antigen (HBsAg) and hepatitis C virus (anti- HCV) in human immunodeficiency virus (HIV) infected patients and to evaluate the results a...
Relationship Between Basic Laboratory Results and Fibrosis in Chronic Hepatitis B Patients
Objectives: Liver biopsy (LB) is an important cornerstone in decision to start treatment for chronic hepatitis B (HB). Viral load and liver function tests are performed to determine the most appropriate time. In this stu...
The Long-term (10.6 years) Outcome of Hepatitis C patients with Sustained Virologic Response Following Treatment with Pegylated Interferon + Ribavirin
Objectives: Directly-acting anti-viral agents for the treatment of hepatitis C have been revolutionised. In the meantime, hepatitis C patients with sustained virologic response (SVR) achieved with previous treatments hav...