FREQUENCY OF HUMAN PAPILLOMA VIRUS IN IRANIAN PATIENTS WITH BLADDER CANCER, KERMAN, SOUTHEAST OF IRAN
Journal Title: INTERNATIONAL JOURNAL OF RESEARCH IN PATHOLOGY AND MICROBIOLOGY - Year 2017, Vol 1, Issue 1
Abstract
To investigate the frequency of human papillomavirus (HPV) in the bladder transitional cell carcinoma (TCC),One hundred twenty paraffin embedded TCC samples were tested for the presence of HPV DNA by Real Time PCR. A consensus MY09/MY11 primer mediated for SYBR Green Real Time PCR technique, and the products were analyzed for specific melting cure. out of 102 samples with TCC, 12 samples (11.76%) were positive for HPV DNA. HPV DNA was detected in patients older 50 years old age. HPV types 16, 18 were high frequency types (32%) in positive samples. The prevalence of HPV DNA in men was almost five times that of women, with ten samples in men (83.3%) and two in women (16.7%) were positive for HPV DNA. These results suggest that HPV can to play an etiological role in the development of urothelial bladder carcinoma. The association of HPV with urothelial bladder carcinoma can vary in different geographical locations. Most studies reporting a high prevalence of HPV in southern Europe or Asia in urothelial bladder carcinoma samples, whereas most carried out in northern Europe and America reported an extremely low rate of HPV in these patients. Therefore, comprehensive and complete studies with more sample size and methods such as microarrays are suggested.
Authors and Affiliations
Reza Malekpour afshar, Arezu Naeim Abadi, Hamid Reza Mollaei, Seyed Alimohammad Arabzadeh
Keywords
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