MORPHOLOGICAL SPECTRUM OF PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS- A SEVEN YEAR STUDY FROM CENTRAL INDIA
Journal Title: INTERNATIONAL JOURNAL OF RESEARCH IN PATHOLOGY AND MICROBIOLOGY - Year 2017, Vol 1, Issue 4
Abstract
INTRODUCTION: Tumors of the nervous system are important cause of cancer-related deaths in children. There are several reports regarding the epidemiology of CNS tumors in children in the Western literature but too few reports from India. Material and Methods-A retrospective study was done on all the pediatric CNS tumors (less than 18 years) that were received in Pathology department over duration of seven years at Bhopal Memorial Hospital and Research Centre, Bhopal, India. All the adult CNS cancers were excluded in the study. All the selected cases were analyzed for age, sex, location of tumour and histomorphological findings, special stain and Immunohistochemical markers. Results: Pediatric CNS tumor constitutes 10.25 %( 48/468) of total CNS tumors. Age range from 3 to 18 years with mean age of 11.2 years, Male: female ratio is 1.1:1. Children (0-14years) accounted for 34 cases with 16 males (47%) and 18 (53%) females. Adolescents (>14-18years) accounted for 14 cases with 9 males (64%) and 5 females (36%). 66.6% tumors are infratentorial or spinal while 33% are supratentorial. Frequency of infratentorial/spinal tumor is high in both children as well as pediatric group. Histopathologically astrocytic tumors were most common (33.6%) and pilocytic astrocytoma(15%) is most frequent astocytic tumor. Embryonal tumours constitute 25.3% cases. Medulloblastoma, NOS (19%) Conclusion: Due to limited resources, in this context, the adequate epidemiologic data is lacking from India. The present study was done to profile the prevalence of pediatric CNS tumors (according to the WHO classification 2016) in a tertiary care setup in Central India having good neurosurgical and neuropathology facilities, and the data was compared with international studies.
Authors and Affiliations
Avinash Gupta, Sukhpreet Kaur, Hanni G Vasudev
Keywords
Related Articles
- EP ID EP656343
- DOI -
- Views 52
- Downloads 0
PRIMARY CUTANEOUS LEIOMYOSARCOMA- 3 CASES REPORT WITH REVIEW OF LITERATURE
Leiomyosarcoma of soft tissue is relatively rare. It is typically a tumor of adults (50-60s). Most soft tissue leiomyosarcomas are located in the extremities. Primary cutaneous leiomyosarcoma of the skin is a rare tumor...
MORPHOLOGICAL SPECTRUM OF PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS- A SEVEN YEAR STUDY FROM CENTRAL INDIA
INTRODUCTION: Tumors of the nervous system are important cause of cancer-related deaths in children. There are several reports regarding the epidemiology of CNS tumors in children in the Western literature but too few re...
RARE SEQUELAE OF HASHIMOTO THYROIDITIS: TWO CASE REPORTS OF MEDULLARY CARCINOMA AND POORLY DIFFERENTIATED CARCINOMA OF THYROID WITH HASHIMOTO THYROIDITIS
Hashimoto thyroiditis (HT) is an autoimmune disease that leads to the destruction of thyroid gland with gradual and progressive hypothyroidism. Individuals suffering from Hashimoto thyroiditis are at an increased risk of...
DIAGNOSTIC ACCURACY AND PITFALLS OF SQUASH SMEAR CYTOLOGY VERSUS PARAFFIN SECTIONS OF GLIAL LESIONS
Diagnosis of central nervous system lesions is always a challenging task for neurosurgeon and neuropathologist. There is varied spectrum of CNS lesions, starting from inflammatory lesions to neoplastic lesions, traumatic...
FREQUENCY OF HUMAN PAPILLOMA VIRUS IN IRANIAN PATIENTS WITH BLADDER CANCER, KERMAN, SOUTHEAST OF IRAN
To investigate the frequency of human papillomavirus (HPV) in the bladder transitional cell carcinoma (TCC),One hundred twenty paraffin embedded TCC samples were tested for the presence of HPV DNA by Real Time PCR. A con...