Frequency of Polymorphic Variants of Phase II Genes of GSTM1 and GSTT1 Xenobiotic Biotransformation in Newborns from Ivano-Frankivsk Region of Ukraine
Journal Title: Здоров`я дитини - Year 2014, Vol 5, Issue 56
Abstract
To determine the allelic polymorphism of glutathione-S-transferases genes GSTM1 and GSTT1 in healthy newborns, premature infants and infants with intrauterine growth retardation we conducted molecular genetic study of umbilical cord blood. To determine the individual response of the genome of a newborn on the possible toxic effects we used the micronucleus test. It is found that in all newborns from the region the frequency of polymorphic variant GSTM1+ was 43.70 %, the frequency of GSTM1– polymorphic variant — 56.30 %. For GSTT1 gene frequency of polymorphic variant GSTT1+ and GSTT1– was 80.67 and 19.33 %, respectively. Positive micronucleus test in neonates was associated with polymorphic variants of GSTM1– — 71.95 % of cases compared with 21.62 % for negative micronucleus test. In the carriers of the GSTT1– polymorphic variant in any case there was no evidence of a positive micronucleus test, in all newborns with negative micronucleus test we found allelic variant GSTT1+. Newborns with negative micronucleus test are characterized by predominance (78.38 %) of genotypes GSTM1+/GSTT1+ association.
Authors and Affiliations
N. G. Gorovenko, S. V. Podolska, Z. R. Kocherga
Keywords
Related Articles
- EP ID EP316596
- DOI -
- Views 104
- Downloads 0
Influence Exogenous Factors on Genomic Imprinting 1. Effect of Nutrition and Provision of Micronutrients in Mother on Genomic Imprinting Descendants
The article analyzes the impact of maternal nutrition during pregnancy on the forming of genomic imprinting in the fetus. It was shown that changes in DNA methylation of imprinted genes, induced by infringement of provid...
Classic galactosemia: features of diagnosis and treatment
Background. Galactosemia type I, or classic galactosemia (CG), is the most severe form of hereditary disorders of carbohydrate metabolism, in particular, galactose. Galactosemia is not included in the program of massive...
Cephalosporins for Treatment of Respiratory Diseases in Outpatient Pediatric Practice
.
Diagnosis and Treatment of Inguinoscrotal Hernias in Children
Introduction. Inguinal hernia — the most common disease in the practice of pediatric surgeon and ranged from 70 to 85 % of all hernias in children. The aim of our work is to improve the results of diagnosis and treatment...
Assessment of Risk Factors for Possible Toxocariasis Invasion in Lugansk Region Population
Toxocariasis — parasitosis-zoonosis which is widespread among animals and humans. The objective of study was to investigate factors that determine the possibility of toxocariasis invasion in population of Lugansk region...