Frequency of Uterine Malformation among Women in a Restricted Gene Pool Community A retrospective cross-sectional study in La Crete, Canada
Journal Title: Sultan Qaboos University Medical Journal - Year 2007, Vol 7, Issue 2
Abstract
Objective: Tis random retrospective cross-sectional study was done to determine the incidence of uterine malformation in 4 groups of women desiring to conceive during their reproductive years, all of them living in La Crete, a community in Northern Alberta, Canada, with endogamous marriage practices in a 500 year old restricted gene pool. Methods: During 2003-2006, eight hundred women, suspected of having uterine malformation, were scanned using 2-D abdominal and transvaginal sonography (TVS). A sub-group of 56 patients was identified with suspected uterine malformations and referred for further diagnostic investigation, including MRI, 3-D sonography, hysterosalpingography, hysteroscopy and laparoscopy. Tis group included 30 women without previous pregnancies (Group ), 3 women with previous pregnancies and live births (fertile) (Group 2), 40 women with live births and more than 2 miscarriages (Group 3) and 55 women with recurrent miscarriages (infertile) (Group 4). Results: Te overall frequency of uterine malformations was recorded at 9.5% in La Crete women. Ninety five women with recurrent or some miscarriages had more uterine malformation than the other groups. Te incidence in Groups 3 and 4 (infertile) was 60.8% and 39.2% in the fertile Groups  and 2. Te p <0.0 was significant at 95% confidence interval. Conclusion: Tis study has provided new insights into the increasing number of uterine malformations in the population of La Crete. It was 9.5%, 5.5 times higher than that of the general population of (0.% to 3.5%). Tis might indicate an increase in uterine malformations among women in a restricted gene pool community. A combination of TVS, hysterosalpingography, 3-D sonography and MRI are necessary for the precise classification of uterine malformations.Uterine malformations are not rare, but may be increasingly related to consanguinity. Te finding of uterine malformation is more frequent in patients with recurrent miscarriages, especially women with septated, unicornuate, or didelphys uteri.
Authors and Affiliations
Saad Ramzi Ismail| Department of Ultrasound, High Level Hospital, Alberta, Box 1462, Alberta T0H, 1Z0 Canada
Keywords
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