From Precursor/Stem Cells To Cordocytic Phenotypes In The Skin
Journal Title: International Journal of Stem Cell Research and Transplantation (IJST) - Year 2014, Vol 2, Issue 1
Abstract
This cytohistopathological study was performed to have a better knowledge of the continuum of cellular events, from mesenchymal stem cells to mature cordocytic phenotypes with their morphological heterogeneity and multiple functions in the human skin. We used light microscopy, as well as transmission and scanning electron microscopy to study multiple tissue fragments obtained by skin biopsy from post-burn tissue, surrounding superficial temporal artery, and skin, in cases with urticaria pigmentosa, Fabry’s diffuse angiokeratoma, allergic vasculitis, hypodermitis, as well as basocellular nevomatosis and basocellular carcinoma. Our observations proved that the cordocytes appear from precursor/stem cells only outside the pericytes in the case of nascent dermal vessels, or from mesenchymal cells of the connective tissue surrounding superficial temporal artery within their niches, and they are responsible for multiple functions, especially protective for vessels and nerves in the reticular dermis. Their spatial and temporal interactions, either with each other or with another phenotype, undifferentiated or differentiated cells, and their implications in skin diseases, with changing phenotypes, position, and number, merit much more interest in further comprehensive studies. Our results showed that these protective interstitial cells promote useful interactions, influencing differentiation and fate of cells closely surrounded by them, as well as preventing or delaying some pathological processes.
Authors and Affiliations
Viorel Pais
Keywords
Related Articles
- EP ID EP195189
- DOI 10.19070/2328-3548-140009
- Views 91
- Downloads 0
Central Pontine Myelinolysis Associated with Cyclosporine in a Patient with NK Cell Leukaemia after Hematopoietic Stem Cell Transplantation
Central pontine myelinolysis (CPM) has been described as a rare complication of liver transplantation. Cases in allogeneic hematopoietic stem cell transplant are less reported. We present a patient with NK cell leukaemia...
Regulations of Regenerative Medicine Including Clinical Application of iPS Cells in Japan
Clinical studies of regenerative medicine using induced pluripotent stem (iPS) cells have recently been performed, especially in Japan. To promote regenerative medicine research using iPS cells, the related laws have bee...
Human Umbilical Cord Matrix - Derived Stem Cells Show Tropism Towards the Human Glioma Microenvironment
Objective: Glioblastoma multiforme (GBM) is an aggressive type of brain tumor in humans. The median survival of patients is a year after diagnosis. It is a great challenge to identify new therapeutic strategies that coul...
Differentiation of Neural Progenitor Cells from Pluripotent Stem Cells in Artificial Niches
Neural progenitor cells (NPCs) derived from pluripotent stem cells (PSCs) provide a promising cell source for disease modeling, drug screening, and tissue engineering. To fulfill the potentials of PSC-derived NPCs, a ser...
Renal Transplantation from Donation After Circulatory Death Donors: Evolution of Strategies
Renal Transplantation from Donation After Circulatory Death Donors: Evolution of Strategies