From Precursor/Stem Cells To Cordocytic Phenotypes In The Skin
Journal Title: International Journal of Stem Cell Research and Transplantation (IJST) - Year 2014, Vol 2, Issue 1
Abstract
This cytohistopathological study was performed to have a better knowledge of the continuum of cellular events, from mesenchymal stem cells to mature cordocytic phenotypes with their morphological heterogeneity and multiple functions in the human skin. We used light microscopy, as well as transmission and scanning electron microscopy to study multiple tissue fragments obtained by skin biopsy from post-burn tissue, surrounding superficial temporal artery, and skin, in cases with urticaria pigmentosa, Fabry’s diffuse angiokeratoma, allergic vasculitis, hypodermitis, as well as basocellular nevomatosis and basocellular carcinoma. Our observations proved that the cordocytes appear from precursor/stem cells only outside the pericytes in the case of nascent dermal vessels, or from mesenchymal cells of the connective tissue surrounding superficial temporal artery within their niches, and they are responsible for multiple functions, especially protective for vessels and nerves in the reticular dermis. Their spatial and temporal interactions, either with each other or with another phenotype, undifferentiated or differentiated cells, and their implications in skin diseases, with changing phenotypes, position, and number, merit much more interest in further comprehensive studies. Our results showed that these protective interstitial cells promote useful interactions, influencing differentiation and fate of cells closely surrounded by them, as well as preventing or delaying some pathological processes.
Authors and Affiliations
Viorel Pais
Keywords
Related Articles
- EP ID EP195189
- DOI 10.19070/2328-3548-140009
- Views 99
- Downloads 0
Bioscaffold Augmentation of the Alveolar Bone: A Pilot Study in the Rabbit to Define the Protocol
Purpose: The current study aims to establish, for the first time, a model to determine the surgical and tissue processing protocols for testing the use of a synthetic bone graft material to augment the contour and volume...
Is There Blinding Onchocerciasis in Northern Uganda?
Background: Onchocerciasis is a filarial nematode Onchocerca volvulus transmitted by female black flies which breeds in fast flowing rivers. Clinical manifestations is ocular or skin lesions. The long-term armed conflict...
ISW for the Treatment of Adult Angle Class I Crowding with Acceptable Lateral Profile Case
This article describes a 34-year-old adult female with chief complaint of poor dental alignment. She presented with Angle Class I crowding with acceptable lateral profile and had been treated with a non-extraction approa...
Regenerative Medicine and Stem Cell Therapies
Regenerative Medicine and Stem Cell Therapies
Search for Chemically Defined Culture Medium to Assist Initial Regeneration of Diseased Renal Parenchyma After Stem/Progenitor Cell Implantation
Before an intended implantation stem/progenitor cells are usually kept in the beneficial atmosphere of a selected culture medium. However, after implantation the situation is drastically changing for them. Yet stem/proge...