FRONTAL AND CALLOSAL WHITE MATTER CHANGES AND THEIR POTENTIAL EFFECTS ON NEUROCOGNITIVE FUNCTIONING IN ALCOHOL ADDICTS: A META-ANALYSIS
Journal Title: Acta Neuropsychologica - Year 2019, Vol 17, Issue 2
Abstract
This meta-analysis of published studies examines the fractional anisotropy coefficient of frontal and callosal microstructural abnormalities in alcohol addiction. Twelve articles (total Nalc = 230) were included. Eighteen of the examined data points concern changes in the corpus callosum, twenty-three point to alterations in frontal white matter tracts, and eleven described microstructural tracts having potential effects on cognitive functions such as short-term and working memory, decision making, selective attention, and visuospatial ability. The random effect models show a standardized mean difference in the particular fiber tracts in all studies: SMDall = 1.20, SMDcc = 1.26, SMDfwm = 1.17, SMDcog = 1.07. The heterogeneity ranges from very low (CC) to high (FWM). In summary, these results confirm and provide significant evidence that callosal and frontal microstructural abnormalities are present in the course of alcohol addiction. This findings also highlight the necessity to further examine patients’ cognitive functioning.<br/><br/>
Authors and Affiliations
Natalia Nowaczyk
Keywords
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