CLINICAL CHARACTERISTICS AND POSSIBLE MECHANISMS UNDERLYING BEHAVIORAL AND PERSONALITY CHANGES IN FTDP-17
Journal Title: Acta Neuropsychologica - Year 2013, Vol 11, Issue 2
Abstract
Although the clinical and neuroanatomical characteristics of behavioral and personality changes have been well-defined in frontotemporal dementia syndromes, relatively little is known about the behavioral and personality changes in frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17). Thus, the aim of this study was to longitudinally characterize the behavioral and personality abnormalities associated with FTDP-17.We examined three patients with a clinical diagnosis of FTDP-17 confirmed by genetic testing. In all three patients the P301L MAPT mutation was detected. All patients underwent neuroimaging (MRI and SPECT). Behavior and personality changes were assessed longitudinally with the Blessed Dementia Rating Scale, the Frontal Behavioral Inventory and/or the Neuropsychiatric Inventory. All three patients demonstrated marked and progressive changes in behavior and personality, as revealed by clinical observation and longitudinal assessment. These abnormalities included mainly disinhibition, indifference, and apathy, as well as compulsive-like and utilization behavior. Nonetheless, as the disease progressed, negative symptoms dominated the clinical presentation of all cases.The common behavioral and personality abnormalities in FTDP-17 with MAPT seem to overlap with the behavioral variant FTD. Also, early behavioral and personality changes in FTDP-17 with MAPT are likely associated with the initial locus of neurodegeneration, and may represent an effect of the disease-related dynamic imbalance between the mutually inhibitory inter- and intrahemispheric processes, which may also possibly account for symptom change as the disease progresses, eventually resulting in an unified behavioral profile of negative symptoms.
Authors and Affiliations
Michał Harciarek, Emilia Sitek, Ewa Narożańska, Seweryna Konieczna, Dariusz Wieczorek, Bogna Brockhuis, Piotr Lass, Mirosława Dubaniewicz-Wybieralska, Maria Barcikowska, Jarosław Sławek
Keywords
Related Articles
- EP ID EP55428
- DOI -
- Views 125
- Downloads 0
CHANGES OF MOOD AND ATTENTION DIVISIBILITY IN ROWERS EXPOSED TO HIGH-INTENSITY TRAINING
Higher probability of succeeding in competitive sports is to a large extent associated with psychological preparation. Emotional and cognitive functioning are important factors that can modulate the attitude of c...
EXTERNALIZING AND INTERNALIZING PSYCHOPATHOLOGY IN CHILDREN WITH ADHD COMBINED TYPE VERSUS ADHD INATTENTION TYPE
[b]Background.[/b] ADHD is characterized by inattention, impulsiveness and hyperactivity, but the clinical picture of ADHD seems to be broader than these behaviors. A high rate of overlap between ADHD and psychiatric dis...
ROLE OF EARLY-CHILDHOOD REFLEXES IN THE PSYCHOMOTOR DEVELOPMENT OF A CHILD, AND IN LEARNING
Background: The aim of this paper is to present the occurrence of primitive reflexes in children with learning difficulties, and, in particular, to establish whether these are the vestigial forms of primitive reflexes oc...
The diagnosis and therapy of aphasia in the acute phase
Communication disorders, including aphasia. accompany central nervous system damage of various origin. Comprehensive rehabilitation – provided from the beginning of hospitalization, adjusted to the general state of healt...
THE HISTORY OF DEVELOPMENTAL NEUROPSYCHOLOGY
This paper deals with the theory of the social genesis of higher mental functions (HMF) developed by Vуgotsky and Luria. Their systemic cultural-historical approach, the first premise of developmental neuropsychology, st...