FTIR-spectrophotometric analysis of levosulpiride and its pharmaceutical formulations
Journal Title: International Journal of Pharmaceutical Chemistry and Analysis - Year 2018, Vol 5, Issue 3
Abstract
A fourier transform infrared FTIR spectrometric method was developed for the rapid direct determination of levosulpiride in different pharmaceutical products13 The universal ATR spectra were recorded and used for this study Multiple linear regression MLR where a restricted set of absorption band is used for calibration beerlambert law was used for data processing A recovery of 985 of levosulpiride from the tablet dosage form with a correlation coefficient of 0996 was obtained The aim of this study was to develop a FTIR spectrophotometric procedure for the analysis of levosulpiride in raw material and tablets The linear regression equation for levosulpiride was calculated to be y1890415239x where x and y are concentration and integrated peak area respectively The method had excellent reproducibility for the standard of 50 mg 495 102 mg n 6 The recovery test is an experimental design to verify the relationship between the amount of substance added and the amount quantified by this assay In this test the observed concentrations of pure levosulpiride in the powdered tablets were not significantly different from the stated concentrations by student39s t test p 005 10004 149 n 3 the method gave rise to linear data in the range 250 Mg with accuracy and precision in the range 07732 Therefore this FTIRspectrophotometric assay was accurate and may be recommended for the simple quantification of levosulpirideKeywords FTIR Levosulpiride ZnSe AUC
Authors and Affiliations
Prasanth S. S, Sruthi K, Kamarunnisa K, Drisya N. K, Ashyam K
Keywords
Related Articles
- EP ID EP481455
- DOI 10.18231/2394-2797.2018.0025
- Views 62
- Downloads 0
A review on quality by design
Quality by design QbD is an essential part of the modern advance to pharmaceutical quality Quality has been given an importance by all regulatory body for pharmaceutical products Quality means customer satisfaction in te...
Role of zinc-aspirin metal coordination complex in diabetic cataract induced in vitro in goat eye lens
Diabetes is one of the major health problems that affect a large number of human populations Diabetic cataract is one of the most frequent ocular complications rising secondarily to the diabetes Aspirin and its various c...
A Review on - Amlapitta in Kashyapa Samhita
Amlapitta is most common disorders in the society nowadays, due to indulgence in incompatible food habits and activities. In Brihatrayees of Ayurveda, scattered references are only available about Amlapitta. Kashyapa Sam...
Analysis and characterization of cefixime by using IR, HPLC and gas chromatography
To develop a new simple sensitive accurate and economical analytical methods for the estimation of related compounds in Cefixime formulations Validate the proposed methods in accordance with USP EUROPE and ICH guidelines...
Inadvertent doping with the use of herbal preparations: is it a reality?
The use of performance enhancing drugs in sports is prohibited by World Anti-doping Agency (WADA).(1) Herbal preparations are usually considered safe due to least side effects but may contain substances which are prohibi...