FTIR-spectrophotometric analysis of levosulpiride and its pharmaceutical formulations
Journal Title: International Journal of Pharmaceutical Chemistry and Analysis - Year 2018, Vol 5, Issue 3
Abstract
A fourier transform infrared FTIR spectrometric method was developed for the rapid direct determination of levosulpiride in different pharmaceutical products13 The universal ATR spectra were recorded and used for this study Multiple linear regression MLR where a restricted set of absorption band is used for calibration beerlambert law was used for data processing A recovery of 985 of levosulpiride from the tablet dosage form with a correlation coefficient of 0996 was obtained The aim of this study was to develop a FTIR spectrophotometric procedure for the analysis of levosulpiride in raw material and tablets The linear regression equation for levosulpiride was calculated to be y1890415239x where x and y are concentration and integrated peak area respectively The method had excellent reproducibility for the standard of 50 mg 495 102 mg n 6 The recovery test is an experimental design to verify the relationship between the amount of substance added and the amount quantified by this assay In this test the observed concentrations of pure levosulpiride in the powdered tablets were not significantly different from the stated concentrations by student39s t test p 005 10004 149 n 3 the method gave rise to linear data in the range 250 Mg with accuracy and precision in the range 07732 Therefore this FTIRspectrophotometric assay was accurate and may be recommended for the simple quantification of levosulpirideKeywords FTIR Levosulpiride ZnSe AUC
Authors and Affiliations
Prasanth S. S, Sruthi K, Kamarunnisa K, Drisya N. K, Ashyam K
Keywords
Related Articles
- EP ID EP481455
- DOI 10.18231/2394-2797.2018.0025
- Views 71
- Downloads 0
Synthesis of novel pyridine containing azetidinone derivatives as a potential anti tubercular activity
Six novel pyridine containing azetidinones Azt 16 have been synthesized from Schiff base by treating Pyridine4carbaldehyde with Substituted aromatic amines each were taken equimolar concentration in presence of Glacial a...
Application of expired drugs in corrosion inhibition of mild steel
Present work deals with the investigation of corrosion inhibition of mild steel using two expired drugs namely Atenolol and Nifedipine in 1 M HCl solution. Their inhibition properties were evaluated using electrochemical...
Bedaquiline –A new drug against multidrug-resistant tuberculosis
The infectious diseases have taken a toll on the rapidly multiplying population of the developing countries The top three killers being HIV AIDS TB and malaria The total number of deaths due to TB is really a cause of co...
Ethnobotanical studies and documentation of folk medicinal plants used by tribes in the management of liver diseases in Satpuda hills of Khandesh region of Maharashtra
West Khandesh region of Maharashtra was targeted areas for ethnobotanical survey of medicinal plants used by tribes in the management of liver diseases and simultaneously documentation was made on information Field of ar...
A mini review on thiadiazole compounds and their pharmacological interest
Various 134thiazole derivatives have been reported to exhibit various biological activities The 134thiadiazole derivatives found to have diverse pharmacological activities such as insecticidal herbicidal antiviral antitu...