Synthesis of novel pyridine containing azetidinone derivatives as a potential anti tubercular activity
Journal Title: International Journal of Pharmaceutical Chemistry and Analysis - Year 2018, Vol 5, Issue 1
Abstract
Six novel pyridine containing azetidinones Azt 16 have been synthesized from Schiff base by treating Pyridine4carbaldehyde with Substituted aromatic amines each were taken equimolar concentration in presence of Glacial acetic acid as a catalyst using Grindstone technique Further Schiff base add benzene triethylamine and chloro acetyl chloride undergoes condensation followed by elimination reaction result into novel pyridine containing azetidinone derivatives The newly synthesized derivatives were characterized by using spectroscopic methods IR 1HNMR MASS and screened for selected antitubercular In vitro antitubercular activity was performed using Micro plate Alamar Blue Assay MABA method Among synthesized compounds Azt5 and azt6 showed more potent Anti TB activity than standardsKeywords Pyridine4carbaldehyde Schiff base Azetidinones antitubercular activity
Authors and Affiliations
N. Pramod, B. Mayuri
Keywords
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- EP ID EP481427
- DOI 10.18231/2394-2797.2018.0007
- Views 57
- Downloads 0
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