Fulminant Invasive Pulmonary Aspergillosis In Immunocompetent Patients A Report of two Cases
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 6
Abstract
Two cases of invasive aspergillosis (IA) in immunocompetent patients with a fulminant fatal outcome are reported. Both patients had a history of chronic lung disease treated with prolonged corticosteroid inhalation and a short course of systemic corticosteroids. They presented with dyspnea and fever, their respiratory function deteriorated rapidly and they succumbed to the disease. Aspergillus fumigatus was cultured from deep tracheal aspirate (DTA) samples of both patients. In the first case, IA diagnosis was confirmed by thoracic CT scan along with isolation of Aspergillus fumigates in blood culture. These two cases demonstrate that short term systemic corticosteroid therapy in immunocompetent patients with underlying chronic lung condition is a risk factor for IA. Invasive aspergilosis should be suspected in COPD patients receiving steroid treatment who have extensive pulmonary infiltrates in initial chest X-ray. More judicious use of corticosteroids may help prevent occurrances of IPA ( invasive pulmonary aspergillosis ) with its attendant serious morbidity and high mortality.
Authors and Affiliations
Ghosh (Ray) Reena
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