Evaluating In Vivo-In Vitro Correlation Using a Bayesian Approach

A Bayesian approach with frequentist validity has been developed to support inferences derived from a “Level A” in vivo-in vitro correlation (IVIVC). Irrespective of whether the in vivo data reflect in vi...

A Novel MDR1 GT1292-3TG (Cys431Leu) Genetic Variation and Its Effect on P-glycoprotein Biologic Functions

P-glycoprotein (P-gp) is a membrane-bound transporter protein that is encoded by the human multidrug resistance gene MDR1 (ABCB1). P-gp recognizes a wide range of xenobiotics, is pivotal in mediating cancer drug resistan...

Erratum to: In Vitro Considerations to Support Bioequivalence of Locally Acting Drugs in Dry Powder Inhalers for Lung Diseases

The online version of the original article can be found at 10.1208/s12248-009-9121-4.

PEITC Induces G1 Cell Cycle Arrest on HT-29 Cells Through the Activation of p38 MAPK Signaling Pathway

Phenethyl isothiocyanate (PEITC), an isothiocyanate abundantly found in cruciferous vegetables have been shown to induce apoptosis through MAPK pathway in prostate and colon cancer cells. In the present study, we investi...

Fish Drug Analysis—Phish-Pharm: 2011 Update