Functional dyspepsia and immune dysfunction: modern concepts of pathogenetic mechanisms of their development
Journal Title: Сучасна гастроентерологія - Year 2018, Vol 0, Issue 1
Abstract
The review presents the main modern opinions on the immunological factors of functional dyspepsia development and data on its micromorphological basis. The immune dysfunction is considered as an important factor in the pathogenesis of functional dyspepsia at different levels, the local level (in a form of duodenal eosinophilic infiltration with eosinophils’ degranulation of and mastocytosis) and general level (imbalance of cellular and humoral immunity with the predominance of pro-inflammatory cytokines). The prospects of further studying the features of immune dysfunction in the development of functional dyspepsia have been substantiated.
Authors and Affiliations
O. Yu. Gubska, T. S. Alianova
Keywords
Related Articles
- EP ID EP276255
- DOI -
- Views 171
- Downloads 0
The features of vegetative and emotional disorders at chronization of duodenal ulcer
Traditionally, duodenal ulcer is referred to the psychosomatic disorders. Not by accident, in the classic investigations of the founder of the stress theory, Canadian scientist R. Selye, acute gastric ulcer serves as a m...
Gastroesophageal reflux disease in patients with metabolic syndrome: the peculiarities of clinical course and the modern approaches to treatment
The article presents a data on prevalence of gastroesophageal reflux disease and Barrett’s esophagus in patients with metabolic syndrome. The main etiopathogenetic mechanisms of formation and modern approaches to therapy...
The role of intestinal microbiome in the progression of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is considered an important and economically significant public health problem, its progression can result in development of cirrhosis and hepatocellular carcinoma. Over the past...
The use of proton pump inhibitors in the general clinical practice: advantages and disadvantages
The article presents modern views on the use of proton pump inhibitors in clinical practice with account of the patients’ age, therapyduration and comorbidity. The analysis has been performed for the literature data and...
Vegetative accompaniment of the combined course of gastroesophageal reflux disease in young patients with autoimmune thyroiditis
Objective — to establish the presence of autonomic dysfunction and to assess the frequency and severity of its manifestations in patients with autoimmune thyroiditis (AIT) and gastroesophageal reflux disease (GERD) with...