FUROXAN DERIVATIVES AS NITRIC OXIDE DONORS AND THEIR THERAPEUTIC POTENTIAL
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 9
Abstract
Nitric oxide synthesized in endothelial cells that line blood vessels, was first described in 1980 as an endothelium derived vascular relaxing factor. It is an important signalling molecule in various pathological and physiological processes. Dysfunction of NO formation has been implicated in the pathogenesis of a number of disorders. Exogenous NO sources constitute a powerful way to supplement NO when the body cannot generate enough for normal biological functions. Furoxan, 1,2,5-oxadiazole 2-oxide, has been a very important scaffold in Medicinal Chemistry as nitric oxide (NO) donor. This article explores some of the most promising recent advances in NO donor drug development. Major focus is placed on recently developed Furoxan derivatives as NO donors and their pharmacological actions.
Authors and Affiliations
Mohammad Amir, Sana Tariq , Somakala Kanagasabai
Keywords
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- EP ID EP132956
- DOI 10.7897/2230-8407.069115
- Views 112
- Downloads 0
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