Gadolinium-based Contrast Agents: Evaluation of Effect On Renal Function Parameters
Journal Title: ​International Journal of Contemporary Medicine surgery and Radiology - Year 2018, Vol 3, Issue 1
Abstract
Introduction: Earlier studies have been carried out to examine the clinical safety of gadolinium-based contrast agents currently available. The primary objective of the study was to study the effect of gadolinium-based contrast agents (Gadodiamide) on renal function based on and creatinine clearance and serum creatinine in patients without any preexisting renal disease. We also aimed to evaluate the effect of gadolinium-based contrast agents on renal functions in patients with diabetes and hypertension who were well controlled with oral medications. Materials and Methods: A prospective cross sectional was study on a total of 47 patients who underwent Contrast-enhanced magnetic resonance imaging(CEMR). Renal function analysis was done based on serum creatinine and creatinine clearance levels which were performed 24 hours prior to CEMR and between 24- 48 hours after CEMR. The effect of contrast media on the renal system was observed with statistical comparison of pre and post CEMR values of serum creatinine and creatinine clearance. Results: Out of 47 patients, We found that there was minimal dip in the serum creatinine values of post CEMR (0.72mg/dL) as compared to that of pre CEMR (0.75mg/dL) We did not find any significant increase in creatinine clearance values post CEMR and in patients with Diabetes mellitus and hypertension. Conclusion: Renal functions are better evaluated with a combination of serum creatinine and creatinine clearance than serum creatinine alone. The administration of GBCA in patients undergoing CEMRI has shown to be safe in patients with normal renal function, but consideration should be given to the potential benefit of the examination and the expected low risk of developing Contrast-induced nephropathy
Authors and Affiliations
Abishek Balachandran, Prachi Kala, Suresh Ashwathappa, Mary Varunya, Raja Kollu, Ramprakash H. V
Keywords
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