Gadolinium-based Contrast Agents: Evaluation of Effect On Renal Function Parameters
Journal Title: ​International Journal of Contemporary Medicine surgery and Radiology - Year 2018, Vol 3, Issue 1
Abstract
Introduction: Earlier studies have been carried out to examine the clinical safety of gadolinium-based contrast agents currently available. The primary objective of the study was to study the effect of gadolinium-based contrast agents (Gadodiamide) on renal function based on and creatinine clearance and serum creatinine in patients without any preexisting renal disease. We also aimed to evaluate the effect of gadolinium-based contrast agents on renal functions in patients with diabetes and hypertension who were well controlled with oral medications. Materials and Methods: A prospective cross sectional was study on a total of 47 patients who underwent Contrast-enhanced magnetic resonance imaging(CEMR). Renal function analysis was done based on serum creatinine and creatinine clearance levels which were performed 24 hours prior to CEMR and between 24- 48 hours after CEMR. The effect of contrast media on the renal system was observed with statistical comparison of pre and post CEMR values of serum creatinine and creatinine clearance. Results: Out of 47 patients, We found that there was minimal dip in the serum creatinine values of post CEMR (0.72mg/dL) as compared to that of pre CEMR (0.75mg/dL) We did not find any significant increase in creatinine clearance values post CEMR and in patients with Diabetes mellitus and hypertension. Conclusion: Renal functions are better evaluated with a combination of serum creatinine and creatinine clearance than serum creatinine alone. The administration of GBCA in patients undergoing CEMRI has shown to be safe in patients with normal renal function, but consideration should be given to the potential benefit of the examination and the expected low risk of developing Contrast-induced nephropathy
Authors and Affiliations
Abishek Balachandran, Prachi Kala, Suresh Ashwathappa, Mary Varunya, Raja Kollu, Ramprakash H. V
Keywords
Related Articles
- EP ID EP424122
- DOI -
- Views 119
- Downloads 0
Detection of Coronary Artery Anomalies using 64 Slice MDCT Angiography
Introduction: Coronary artery anomalies are uncommon conditions of congenital origin with an incidence ranging from 0.17% in autopsy cases to 1.2% in cases undergoing conventional angiography. Coronary artery anomalies w...
Fasting and Postprandial Lipid Profile in Type 2 Diabetes Mellitus: A Comparative Study
Introduction: Globally the incidence of type 2 DM is increasing due to various factors like a high level of insulin resistance, genetic predisposition, and environmental factors. Hyperglycemia characterizes type 2 DM due...
Infected Complex Odontoma – A Case Report
Introduction: Odontomas are benign, painless slow growing tumors with compound and complex variants. It has been classified as complex and compound odontomas. Complex odontoma is a tumor of mixed tissue origin. It is mos...
Usefulness Assessment of Preoperative MRI Fistulography in Perianal Fistulas Patients
Introduction: Perianal fistulas with a complex, branched and high course, especially in patients after previous surgeries or patients with Crohn disease. Aim: Application of MRI fistulography for evaluation of cases of p...
Computed Tomographic Findings of chest in Cases of HIV and Correlation with CD4 Counts- A Three Year Study at a Tertiary Care Hospital
Introduction: According to global report, 36.7 million people worldwide are living with AIDS by end of 2016, with 2.1 million children <15 years of age. The primary cell involved in AIDS is CD4 T-lymphocyte; hence the es...