Ganciclovir eye gel and spleen ammonia peptide for epithelial herpes simplex keratitis
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 11
Abstract
AIM: To study the clinical effects of ganciclovir eye gel combined with spleen ammonia peptide oral freeze-dried powder in the treatment of epithelial herpes simplex keratitis(HSK).<p>METHODS: Totally 70 cases(70 eyes)with HSK diagnosed in Ophthalmology Department of our hospital from January 2015 to June 2016 were enrolled. All the patients were divided into control group and experimental group randomly. Control group was treated by ganciclovir eye gel, 6 times per day; while experimental group was treated by ganciclovir eye gel combined with spleen ammonia peptide oral freeze-dried powder, administered by cool white boiling water at daily bedtime, 2 milligram of every time. All patients were treated for 30d. Then the therapeutic effects of two groups, including the cure rate, time of corneal ulcer healing, pain relief, photophobia disappeared, vision improvement and recurrence rate were compared and analyzed.<p>RESULTS: The therapeutic effects of experimental group was better than the control group. The cure rate was 80% for experimental group and 51% for control group. The clinical cure rate in experimental group was significantly higher than that of the control group(<i>P</i><0.05). The time for corneal ulcer healing and pain relief and photophobia disappeared in experimental group was significantly shorter than that for the control group(<i>P</i><0.05). The recurrence rate in the 1-year follow-up was 14% for experimental group and 67% for control group. The clinical recurrence rate in experimental group was significantly lower than that of the control group(<i>P</i><0.05).<p>CONCLUSION: The application of ganciclovir eye gel combined with spleen ammonia peptide oral freeze-dried powder in epithelial herpes simplex keratitis, which improves visual acuity, the cure rate and shortens the course of disease and reduces the recurrence rate, is the ideal treatment of epithelial herpes simplex keratitis at present.
Authors and Affiliations
Jin-Lan Wan
Keywords
Related Articles
- EP ID EP519571
- DOI 10.3980/j.issn.1672-5123.2018.11.28
- Views 102
- Downloads 0
Influence of microkeratome and femtosecond laser on vision and corneal flap thickness used in corneal flap making
AIM: To study and compare the influence situation of corneal flap made by microkeratome and femtosecond laser for the vision and corneal flap thickness in patients. <p>METHODS: Totally 120 patients(240 eyes)with myopic r...
Effect of microRNA-155 on the pathogenesis of primary open angle glaucoma
microRNA is specifically expressed in ocular tissues and plays a unique role in ocular tissues. microRNA-155 regulates a variety of signaling pathways, affects the expression of the corresponding protein, then leads to t...
Clinical features and prognosis of ocular injuries during Spring Festival
AIM: To summarize and analyze the clinical data of patients with ocular injuries during Spring Festival in the past five years, and analyze the effect of injury on the patient and visual outcome.<p>METHODS: The clinical...
Efficacy of supratarsal injection of triamcinolone acetonide and dexamethasone sodium phosphate in treating paediatric vernal keratoconjunctivitis in suburban Malaysia
This study aims to describe the treatment efficacy of supratarsal injection of triamcinolone acetonide and dexamethasone sodium phosphate for paediatric vernal keratoconjuctivitis(VKC)over a 5-year-period in Hospital Uni...
Effect of scleral buckling with intravitreous gas injection for rhegmatogenous retinal detachment and influence on serum amino acids and VEGF
AIM: To study the clinical curative effect of scleral buckling(SB)combined with intravitreous gas injection in the treatment of rhegmatogenous retinal detachment(RRD)and the influence on serum levels of amino acids and v...