Relationship between autophagy and oxidative stress in diabetic retinopathy
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 7
Abstract
Diabetic retinopathy(DR)is a microvascular and neurological complication of diabetes mellitus. Oxidative stress is an important pathogenic mechanism for the occurrence of DR. Autophagy is a crucial regulatory mechanism of cells under both physiologic and pathologic conditions. It can maintain intracellular homeostasis by degrading redundant or damaged proteins and organelles in cells. Prior studies have documented that there is a strong connection between autophagy and oxidative stress of DR. This article reviewed previous findings regarding the specific relationship between autophagy and oxidative stress in DR, including early microvascular lesions, neuropathy and other pathological changes. The aim of this review is to provide new ideas to clarify the pathogenesis of DR.
Authors and Affiliations
Yan Li
Keywords
Related Articles
- EP ID EP553680
- DOI 10.3980/j.issn.1672-5123.2018.7.11
- Views 117
- Downloads 0
Efficacy evaluation of phacoemulsification with IOL implantation in patients with acute angle-closure glaucoma complicated with cataract
AIM: To study and analyze the clinical effect of phacoemulsification with intraocular lens(IOL)implantation in patients with acute angle-closure glaucoma complicated with cataract. <p>METHODS: From June 2016 to January 2...
Comparison of corneal curvature and astigmatism measurements with four kinds of instruments before cataract surgery
AIM: To compare corneal curvature and astigmatism values identified with OPD-Scan Ⅲ, IOL Master, Pentacam and KR-8900 in cataract patients and to evaluate the consistencies and differences. <p>METHODS: In this prospectiv...
PBL teaching model on cultivating students' clinical thinking in clinical practice teaching of ophthalmology
AIM: To explore the teaching effect of problem-based learning(PBL)on cultivating students' clinical thinking in clinical practice teaching of ophthalmology. <p>METHODS: A total of 141 clinical undergraduate students were...
Effect of scleral buckling with intravitreous gas injection for rhegmatogenous retinal detachment and influence on serum amino acids and VEGF
AIM: To study the clinical curative effect of scleral buckling(SB)combined with intravitreous gas injection in the treatment of rhegmatogenous retinal detachment(RRD)and the influence on serum levels of amino acids and v...
Effect of zinc on galactose-induced cell apoptosis in human lens epithelial cells
AIM:To study the effect of zinc on galactose-induced cell apoptosis in human lens epithelial cells(HLEC). <p>METHODS:HLEC cell line SRA01/04 cells were cultured in DMEM medium and divided into six groups: control group,...