GARCINIA KOLA SEED AND VITAMIN E AMELIORATES ACETAMINOPHEN INDUCED OXIDATIVE STRESS IN ALBINO RATS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 11
Abstract
Acetaminophen, a widely available drug used to treat fever and pains has been reported to exhibit toxic side effects. The study investigated the ameliorating effects of aqueous Garcinia kola seed extract and vitamin E on oxidative stress induced by acetaminophen in albino rats. The results showed that the acetaminophen induced rats were subjected to oxidative stress as was shown by the extent of lipid peroxidation (high malondialdehyde levels) and marked reduction of enzymatic antioxidants (superoxide dismutase, catalase and glutathione peroxidase) levels in the serum when compared with the control. Pretreatment with varied concentration of aqueous Garcinia kola seed extract (800mg/kg, 100mg/kg) and vitamin E (50mg/kg, 25mg/kg) by the oral gavage method for 7 days prior to acetaminophen intraperitoneal administration (800mg) resulted in significant decrease (p<0.05) of malondialdehyde level, increased levels of the activities of SOD, CAT and GPX in the serum thus resulting in reducing the free radicals formation in the blood of the rat. The combined form of pretreatment showed no synergistic effect when compared with the singly pretreatment with either Garcinia kola or vitamin E. These observations demonstrate that aqueous Garcinia kola seed extract and vitamin E possesses antioxidant properties that ameliorates oxidative stress induced by acetaminophen.
Authors and Affiliations
Waribo H. A.
Keywords
Related Articles
- EP ID EP631132
- DOI -
- Views 156
- Downloads 0
SOLITARY RECTAL ULCER SYNDROME MIMICKING RECTAL NEOPLASM ON COLONOSCOPY
We describe a highly unusual case of solitary rectal ulcer syndrome in a 90 years old African American female patient with a history of distal sigmoid colon resection for colon cancer with hysterectomy for uterine cancer...
PHARMACOLOGICAL ASPECT OF ARTEMISININ AND ARESUNATE AS POTENT ANTI MALARIAL AGENTS - OVERVIEW
Artemisinin (ARN) is a natural anti-malarial product which can be isolated from the Chinese medicinal herb Artemisia annua. It comprises a new generation of antimalarial compounds that feature a nitrogenfree sesquiterpen...
EVALUATION OF PHENOLICS, THE NITRIC OXIDE RADICAL SCAVENGING ACTIVITY, AND FERRIC REDUCING/ANTIOXIDANT POWEROF SALICORNIA EUROPAEA
We investigate here the antioxidant capacity in local halophytic species, Salicornia europaea,well known for their ethnopharmacological utilizations in traditional medicine.The objectives of this study were to determine...
THE FREQUENCY AND MANAGEMENTS OF PIERRE ROBIN SEQUENCES AMONG PATIENTS ATTENDING WITH ISOLATED CLEFT PALATE.
Among the cleft lip and palate population, the most common diagnosis is cleft lip and palate at 46%, followed by isolated cleft palate at 33%. Cleft lip and palate may be isolated or associated with another anomalies. Ro...
SEROPREVELANCE OF BRUCELLA AGGLUTININS IN BLOOD DONORS IN KHARTOUM TEACHING HOSPITAL BLOOD BANK
Brucellosis is a zoonosis of both public health and economic significance in most developing countries. In Sudan, the blood donors aren’t screened for brucellosis in spite of the fact that the disease is transmitted thro...