Gastric HCL and ulcerogenic potentials of chloroquine,Fansidar and Metakelfin
Journal Title: Advance Research Journal of Multidisciplinary Discoveries - Year 2019, Vol 33, Issue 33
Abstract
Comparative gastric hydrochloric acid Secretion was studied in males & females albino rats with three antimalaria drugs; chloroquine® fansidar® and metakelfin®. Of the antimalaria drugs studied, Chloroquine was found to increase stomach hydrochloric acid secretion at (P<0.05) in all the four weeks period of observation. However, fansidar increased gastric hydrochloric secretion during the first and second week of observation after its administration (P<0.05) but the secretion was not significant (P<0.05) in the third and fourth week of observation. Metakelfin showed a significant increase in hydrochloric acid secretion in week one, two and four (P<0.05) but insignificant secretion was observed in week three. It is concluded that chloroquine and metakelfin have the tendency of inducing peptic ulcer but fansidar may be a potent drug for peptic ulcer treatment.
Authors and Affiliations
Jimmy E O, Umoh I U
Keywords
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