Gastrointestinal Stromal Tumors –A case series –Our Experience Over Four Years in A Tertiary Care Medical College Hospital
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 7
Abstract
Background: Gastrointestinal stromal tumors (GIST) are mesenchymal tumors and account for 3% of all gastrointestinal malignancies. They are unpredictable, rare, enigmatic and display aggressive behavior1 . They express tyrosine kinase (KIT) and commonly involve small gut and stomach (rarely esophagus, mesentery and colon). A series of 11 cases of GIST managed in a teaching hospital attached to a medical college over 4 years is presented. Methods: Medical records of the 11 cases of GIST managed during January 2013 through December 2016 were reviewed for patient demographics, clinical presentation, investigation, sites, treatment, histology, immunohistochemistry and Imatinib therapy. Follow up for recurrence over the period ranging from 6 months to 4 years was done. Results: GIST was common in men. Age ranged 28 to 75 years. Sites involved were--small bowel in 5, stomach in 2, mesentery in 2, rectum and greater omentum 1 each. Symptoms ranged from abdominal pain, mass, upper /lower gastrointestinal bleeding, small bowel obstruction. Surgery was the mainstay of the treatment. All were positive for tyrosine kinase. One case was non resectable and another showed metastasis to the mesenteric lymph nodes, which is uncommon. All received Imatinib post operatively. Recurrence was seen in one patient with small bowel GIST at 2 years. Conclusions: GIST are uncommon with varied presentations and may be aggressive and can recur. GIST tumors elaborate tyrosine kinase, hence KIT receptor inhibitor Imatinib was useful in all, nonresectable & recurrent tumors. Tyrosine kinase inhibitor has thus drastically changed the diagnosis and management of these tumors.
Authors and Affiliations
Dr Prakash Dave
Comparative study of Olmesartan and Telmisartan on reduction of raised diastolic blood pressure in patient with age more than 40 years
Hypertension is a major risk factor for cardiovascular morbidity and mortality. Antihypertensive drug is used to reduce blood pressure. In addition, angiotensin receptor blocker has shown beneficial effect for controllin...
A Cross-sectional Study on Age related Dyslipidaemia in patients with Type2 Diabetes mellitus
Objectives: This study was to evaluate the effect of duration of diabetes mellitus on lipid profile of different age groups patients, establish the relation between serums lipid profile of patients with type 2 Diabetes m...
Microfilariae in Breast Fine Needle Aspiration- an Unusual Finding
Filariasis is a major public health problem particularly in tropical countries like India. The presence of microfilaria using fine needle aspiration cytology has been reported from various sites. However, the presence of...
Prevalence and Correlates of Technostress among Academic Staff at the University of Jos, Nigeria
Background: Technostress is one aspect of stress on the job which in turn is increasingly recognized as a major organizational problem. The considerable amount of time spent on the computer and electronic gadgets by acad...
Frequency of HBV and HCV among Patients Undergoing Elective Surgery in a Tertiary Care Referral Hospital in Duhok, Iraqi Kurdistan
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections possess occupational hazard to health care workers (HCWs) particularly surgeons, anesthetists, nurses and theater staff. Reliable epidemiological data on fre...