GASTROPROTECTIVE POTENTIAL OF LASIA SPINOSA IN ALBINO RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 3
Abstract
Objective: The intent of the present study was to assess the gastroprotective impact of Lasia spinosa leaf ethanolic concentrate (LSEE) by method of Indomethacin and Cold Restrain stress induced Ulcers in Albino rats. Lasia spinosa is a plant found in Assam on rough slope top of dry deciduous timberlands.Methods: Indomethacin 5mg/kg body weight p. o; for five days and Cold restraint stress models, were utilized for actuating gastric ulcers in rats. Biochemical parameters such as Glutathione, Malondialdehyde, acidity, Gastric volume, gastric pH were determined in order to assess the gastro protective activity of LSEE in both the models.Results: Treatment of rats with Indomethacin and subjecting them to Cold restraint stress (CRS) elevated the levels of Gastric volume, acidity, Glutathione, Malondialdehyde and gastric pH in negative control group in comparison with normal group. The elevated levels were significantly reversed when treated with standard drug Ranitidine 50 mg/kg body weight p. o; and Lasia spinosa leaf ethanolic extracts (LSEE).Conclusion: All in all it can be expressed that Lasia spinosa leaf ethanolic concentrates demonstrated a critical inversion of ulcerative parameters. It could be imagined that it applies its action because of the vicinity of flavonoids which have been accounted for to secure the mucosa by development of a defensive layer.Â
Authors and Affiliations
Mohammed Atif, Syed Baquer Mahmood
Keywords
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