GASTRORETENTIVE DRUG DELIVERY SYSTEM: STOMACH SPECIFIC MUCOADHESIVE TABLET
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 12
Abstract
The current article focuses on the principles of mucoadhesive drug delivery systems based on adhesion to biological surfaces that are covered by mucus. Bioadhesion can be defined as the process by which a natural or a synthetic polymer can adhere to a biological substrate. When the biological substrate is a mucosal layer then the phenomena is known as mucoadhesion. Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effect. Mucoadhesion is defined as the ability of material adheres to biological tissue for an extended period of time. Mucoadhesive dosage forms extend from the simple oral mucosal delivery to the nasal, vaginal, ocular and rectal drug delivery systems. The success and degree of mucoadhesion bonding is influenced by various polymer-based properties. Evaluation of such mucoadhesive formulations has transgressed from first-generation charged hydrophilic polymer net-works to more specific second generation systems based on lectin, Thiol and various other adhesive functional groups. Various theories are consider like Electronic theory, Wetting theory, Absorption theory, Fracture theory in mucoadhesion. Various In vitro and In vivo tests carried out for determination of mucoadhesion.
Authors and Affiliations
Mihir Siddhapara , Vijay Tikare , MV Ramana, Bhavesh Sutariya
Keywords
Related Articles
- EP ID EP108574
- DOI -
- Views 120
- Downloads 0
STANDARDIZATION OF IN HOUSE PREPARED POLYHERBAL FORMULATION NIRMALAYA CHURNA
Standardization of herbal formulation is essential in order to assess the quality of drugs for therapeutic value. According to an estimate of World Health Organization (W.H.O) nearly 80% of populations of developing coun...
VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF CARVEDILOL IN TABLETS
Three simple, sensitive, precise and economical UV- spectrophotometric methods have been developed for the determination of Carvedilol in tablet formulation. Method A is simple UV spectrophotometric method and is based o...
IMPROVEMENT OF SOLUBILITY AND DISSOLUTION RATE OF PIROXICAM BY SOLID DISPERSIONS IN PEG4000
The aim of the present study was to enhance the dissolution rate of piroxicam (PX) using its solid dispersions (SDs) with polyethylene glycol (PEG) 6000. The phase solubility behavior of piroxicam in presence of various...
POSSIBLE CARDIAC ADVERSE EFFECTS OF THERAPEUTIC DOSES OF MACROLIDE ANTIBIOTICS (AZITHROMYCIN AND CLARITHROMYCIN) IN HEALTHY JUVENILE RATS: BIOCHEMICAL ASSESSMENT
The drugs are associated with QT interval prolongation and cardiac dysrhythmias. This study was designed to determine whether or not a therapeutic oral dose of either azithromycin or clarithromycin administered for 5 or...
PHYTO SOMES: A NOVEL PHYTO-PHOSPHOLIPID CARRIERS FOR HERBAL DRUG DELIVERY
Advanced biochemical and pre-clinical studies have proved the potential of plant flavonoids, polyphenolics and other hydrophilic natural compounds for the treatment of skin disorders, different types of carcinoma, anti-a...