IMPROVEMENT OF SOLUBILITY AND DISSOLUTION RATE OF PIROXICAM BY SOLID DISPERSIONS IN PEG4000
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
The aim of the present study was to enhance the dissolution rate of piroxicam (PX) using its solid dispersions (SDs) with polyethylene glycol (PEG) 6000. The phase solubility behavior of piroxicam in presence of various concentrations of PEG 6000 in distilled water was obtained at 37 °C. The solubility of PX increased with increasing amount of PEG 6000 in water and demonstrating that the reaction conditions became more favorable as the concentration of PEG 6000 increased. The SDs of PX with PEG 6000 were prepared using 1:1, 1:2,1:3,1:4 and1:5 (PX/PEG 6000) ratio by Hot-melt method and solvent evaporation method. Evaluation of the properties of the SDs was performed by using dissolution, Fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC). The SDs of PX with PEG 6000 exhibited enhanced dissolution rate of PX and the rate increased with increasing concentration of PEG 6000 in SDs. Mean dissolution time (MDT) of PX decreased significantly after preparation of SDs and physical mixture with PEG6000. The FTIR spectroscopic studies revealed that there is no chemical interaction and drug was stable. The DSC studies indicated the microcrystalline or amorphous state of PX in SDs with PEG 6000.
Authors and Affiliations
Parthasarathi Kulkarni , Mudit Dixit , Selvam Panner , Achin Jain
Keywords
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