IN VITRO ANTIRHEUMATOID ARTHRITIC ACTIVITY OF AQUEOUS ROOT EXTRACT OF CLITORIA TERNATEA
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 12
Abstract
In ethano medicine, roots of Clitoria ternatea (Family: Fabaceae) is claimed to possess antirheumatoid arthritic activity. However, this claim has not been scientifically tested and validated yet. This study assessed the antirheumatoid arthritic potential of an aqueous root extract (ARE) of Clitoria ternatea (Family: Fabaceae) using a well recognised in vitro bioassay model: inhibition of heat induced denaturation of albumin protein, which is claimed to act as an index of anti arthritic activity. Five concentrations of ARE (31.25, 62.50, 125, 250 and 500 µg/ml) and six concentrations of reference drug, Diclofenac sodium (78, 125, 156.25, 312.50, 625, 1250 and 2500 µg/ml), were used in the testing. The results showed, for the first time, that ARE of Clitoria ternatea markedly (IC50 = 184.32 ± 1.5 µg/ml) inhibited the heat induced denaturation of albumin protein in a concentration dependent manner (r2 = 0.99). This effect was comparable to the reference drug (IC50 = 252.46 ± 0.18 µg/ml). It is concluded that ARE of Clitoria ternatea possesses anti rheumatic arthritic activity and provide scientific justification for its use in ethanomedicine.
Authors and Affiliations
Ranaweera Bharathee, Ranjith Pathirana , Ambalanduwa Chandana, Jayakody Ralalage Chandra Jayakody, Ratnasooriya Daya
Keywords
Related Articles
- EP ID EP100227
- DOI 10.7897/2230-8407.0512188
- Views 96
- Downloads 0
PROXIMATE BIO-CHEMICAL AND NUTRITIVE COMPOSITION IN LOCAL GENOTYPES OF PRUNUS TRIFLORA OF MANIPUR, INDIA
The North- East state Manipur, India is a powerhouse of many wild flora and fauna. Varied ranges of wild edible Prunus triflora genotypes commonly known as plum are found in valley and hill districts of the region. Each...
A REVIEW ON ETHNOMEDICAL AND TRADITIONAL USES OF MIMOSA PUDICA (CHUI-MUI)
Mimosa pudica (from Latin: Pudica”shy, shrinking” also called sensitive plant and touch me not), is a creeping annual and perennial herb.The species is native to South America and Central America. Mimosa belongs to the t...
COMPARATIVE ANALYSIS OF ANTIMICROBIAL ACTIVITY OF DIFFERENT VARIETIES OF MURRAYA BY USING MOLECULAR MARKER
Murraya koenigii is used as a stimulant, stomachic, febrifuge, analgesic and for treatment of diahrea, dysentery and insect bite. In present study, the antimicrobial activity of different part of Murraya kenigii(leaf, r...
FABRICATION AND CHARACTERIZATION OF GASTRORETENTIVE MUCOADHESIVE MICRO-PARTICULATE SYSTEM OF PIOGLITAZONE HYDROCHLORIDE FOR SUSTAINED DELIVERY
The present study was conducted to formulate and evaluate Gastro retentive Micro-particulate drug delivery system of Pioglitazone Hydrochloride (HCl) for sustained delivery. Pioglitazone Hydrochloride microspheres were p...
SCREENING OF ENDOPHYTIC FUNGI FROM CASSIA SIAMEA LAMK LEAVES AS α-GLUCOSIDASE INHIBITOR
Alpha glucosidase inhibitor is one of therapeutic approaches for diabetes mellitus which is known for its safety compare to other oral anti diabetic drugs. Therefore searching of α-glucosidase inhibitor from natural comp...