GDF11 alleviates the formation of aortic aneurysm by reducing inflammatory responses
Journal Title: Journal of Air Force Medical University - Year 2023, Vol 44, Issue 8
Abstract
Objective To investigate the protective effect of GDF11 on the formation of aortic aneurysm and its effect on inflammatory responses. Methods Sixty 3-week-old male C57BL / 6 mice (10 13 g) were randomly divided into three groups: normal control group (n = 20), aneurysm group (n =20) and aneurysm and GDF11 co-treatment group (n =20). A mouse aneurysm model was constructed with β-aminopropionitrile (BAPN) drinking water, at a dose of 1 g· kg - 1· d - 1. The diameter of aortic vessels, GDF11 and MMP9 protein expression and experession levels of inflammatory factors were detected after 4 weeks. Results After feeding with BAPN, the diameter of aortic vessels enlarged, GDF11 protein expression decreased, while MMP9 protein expression and expression levels of inflammatory factors increased. GDF11 could significantly alleviate the enlargement of aortic diameter, and down-regulate MMP9 protein expression and expression levels of inflammatory factors ( P < 0. 01). Conclusion GDF11 co-treatment can significantly alleviate aortic vasodilation and reduce aortic vascular inflammation.
Authors and Affiliations
XUE Chao, LI Buying, JIANG Liqing, WANG Weiguang, JIN Zhenxiao, DUAN Weixun, REN Kai
Keywords
Related Articles
- EP ID EP724930
- DOI -
- Views 36
- Downloads 0
Morphological study of GABAergic neurons involved in pulpitis pain and related anxiety
Objective To establish a mouse model of experimental pulpitis, detect pain and anxiety-like behaviors, and observe the activation of neurons in insular cortex (IC) and medial prefrontal cortex (mPFC) and the activity ch...
Protective effect of intranasal insulin on memory impairment in mice exposed to high altitude
Objective To explore the protective effect and mechanism of intranasal administration of insulin on memory impairment in mice exposed to high altitude. Methods Eighty female C57BL / 6 mice were randomly divided into no...
Correlation between refractive status and ocular biological parameters among students of grade three in teenagers aviation schools of Air Force
Objective To analyze the correlation between refractive status and ocular biological parameters among students of grade three in teenagers aviation schools of Air Force, and to explore the key monitoring indicators for...
Behavioral study on depression and hyperalgesia induced by chronic restraint stress model
Objective To establish a mouse model of depression with chronic pain symptoms, so as to lay a foundation for exploring neurobiological mechanisms and treatment strategies of depression and pain comorbidity. Methods Adul...
Immune response and intervention strategies of SARS-CoV-2 infection
Emerging viral pathogen infection has a significant impact on global public health security, social and economic development, and human life and health. Coronavirus disease 2019 (COVID-19) causes fever, headache, muscle...