Gender and science

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

The embryonic programme ‘epithelial–mesenchymal transition' (EMT) is thought to promote malignant tumour progression. The transcriptional repressor zinc-finger E-box binding homeobox 1 (ZEB1) is a crucial...

Ion channels: functional expression and therapeutic potential in cancer. Colloquium on Ion Channels and Cancer

It is becoming increasingly clear that TRP channels are involved in cancer progression (Bödding, 2007; Prevarskaya et al, 2007). In relation to prostate cancer, N. Prevarskaya (Villeneuve d'Ascq, France) describe...

Are rafts involved in T-cell receptor signalling? Introduction to the Talking Point on the involvement of lipid rafts in T-cell activation

Have we become overly reliant on lipid rafts? Talking Point on the involvement of lipid rafts in T-cell activation

During the past decade, the lipid-raft hypothesis has focused attention on the role of membrane domains in controlling cellular functions. Among the best-studied roles of lipid rafts is the regulation of T-cell signallin...