Genetic Architecture of Body Fat Composition in Mice

Journal Title: Journal of Natural Science Review - Year 2023, Vol 1, Issue 1

Abstract

Body fat composition is a quantitative measure of obesity, a major health concern in humans. Laboratory mice are considered an excellent model for dissecting the genetic basis of obesity due to the genetic variation present in inbred strains for body size and fat composition, as well as their historical use as a model organism for human disease studies. To identify the loci controlling fat pad weights and body weight in mice, we performed a quantitative trait loci (QTL) analysis of 513 (SM/J x NZB/BINJ) F2 individuals fed a high-fat diet for 14 weeks. Our analysis separated fat composition genetic effects from those affecting overall body sizes in mouse. Composite interval mapping (CIM) results showed that body weight was conditioned by three major additive QTLs, explaining 3 to 30% of the phenotypic variation. One significant QTL on chromosome 19 conditioned all fat pads with the exception of the inguinal fat weight, which was controlled by a different QTL also on chromosome 19. Significant QTLs associated with fat compositions were detected on chromosomes 17 and 19 and differed from those of body weight. The fat pad QTLs also showed mainly additive gene effects and they explained 2 to 7% of variation in fat composition. Joint analysis of correlated traits detected five additional large effect QTLs on five different linkage groups. These findings have indicated that fat composition and body weight in mouse are conditioned by one to three major additive genes and can therefore be potentially manipulated in controlling obesity.

Authors and Affiliations

Muhammad Wali Salari; Patrick Ongom; Amanda Easterly; Qi Wang

Keywords

Related Articles

Impacts of Climate Change on Vector-Borne Diseases of Animals and Humans with Special Emphasis on Afghanistan: A Review

Vectors are organisms that transmit pathogenic microorganisms among animals and humans. Infections transmitted by the bites of blood-sucking arthropods are called vector-borne diseases (VBDs). This review highlights the...

Evaluation of the Past Climate Changes Effects on Potato Growth and Yield by Modeling

Global warming and climate changes and their effects on the phenology stages and production of crops have attracted attention of researchers. We investigated the impacts of climate changes, phenology stages, yield potent...

Evaluation of the Physicochemical Properties of Different Imported Milk Brands Offered in Afghanistan Markets

Milk is an enriched food that humans widely consume. It is the source of many nutrients like protein, fat, carbohydrates, vitamins, and minerals. The content of high-quality milk should match that of natural milk and nat...

Determination of Phenolic and Flavonoid Content in Ziziphus Jujuba Mill. Fruit Collected from Farah Province, Afghanistan

The fruit of jujube (Ziziphus jujuba Mill.), a member of the Rhamnaceous family, is a valuable exporting dry fruit of Afghanistan. The plant is found in some provinces of the country, but Farah province produces it more....

A Study of entomopathogenic nematodes and their role in microbial control of pests

An essential part of managing insect pests is the use of entomopathogenic nematodes and in preventing environmental contamination. Their use has been increasing in recent years. So far, about 30 to 40 nematode families a...

Download PDF file
  • EP ID EP736946
  • DOI https://doi.org/10.62810/jnsr.v1i1.11
  • Views 73
  • Downloads 1

How To Cite

Muhammad Wali Salari; Patrick Ongom; Amanda Easterly; Qi Wang (2023). Genetic Architecture of Body Fat Composition in Mice. Journal of Natural Science Review, 1(1), -. https://europub.co.uk/articles/-A-736946