Genetic Aspect of Clopidogrel Resistance: An Indian Scenario
Journal Title: Indian Journal of Cardio Biology & Clinical Sciences - Year 2016, Vol 3, Issue 1
Abstract
Clopidogrel is an oral, thienopyridine class anti-platelet agent used to inhibit blood clots and is one of the most widely used in patients with coronary artery disease, peripheral vascular diseases, and cerebrovascular disease to prevent myocardial infarction and stroke. However, it has been reported that anti-platelet drugs such as Clopidogrel do not prevent the risk of ischemic events completely leading to a number of reoccurring ischemic events. This non responsiveness is referred as Clopidogrel resistance wherein less than 30% inhibition of the platelet aggregation in response to Clopidogrel is considered as low or weak-response, while less than 10% is termed as Clopidogrel resistance. The variation in response to Clopidogrel from subject to subject has been attributed to several factors such as non-adherence to treatment, poor bioavailability, accelerated platelet turnover, drug interactions; as well as on certain genetic factors. Here we review the variations in the genetic components associated with its transport, activation and target of action in Indian population.
Authors and Affiliations
Kavita K. Shalia
Keywords
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