Genetic Markers for Sex Identification in Forensic DNA Analysis
Journal Title: Journal of Forensic Investigation - Year 2014, Vol 2, Issue 3
Abstract
The ability to determine the sex of an individual based on DNA evidence can be crucial in instances such as identification of victims of mass disaster, missing persons investigations, and sexual assault cases. The Y chromosome marker amelogenin is currently in widespread use for determination of chromosomal sex of an unknown DNA donor and differentiating the relative contributions of male and female DNA in a mixed forensic sample. However, many cases of the failure of the amelogenin marker to correctly determine the sex of DNA donors have been reported, causing the usefulness of the amelogenin marker in forensics to be questioned. In this paper we review use of amelogenin as a marker for sex identification in forensics and describe four additional Y chromosome markers, sex-determining region Y (SRY), Y-encoded testis-specific protein (TSPY), locus DXYS156, and steroid sulfatase (STS). The SRY, TSPY, DXYS156, and STS markers each have properties that could be used for developing more rigorous methods of testing forensic DNA samples for a Y chromosome or the presence of specific reproductive or secondary sex characteristics.
Authors and Affiliations
Richard Li
Keywords
Related Articles
- EP ID EP202486
- DOI 10.13188/2330-0396.1000013
- Views 130
- Downloads 0
Dental Identification of a Mummified Body using Dental Cast and Prosthesis
Forensic dentistry can significantly contribute to the identification of victims especially in cases of charred, decomposing, mutilated or skeletonized bodies. However, in order to make this procedure technically feasibl...
Examination of Genuine and Fake Images by Histogram and Edge Detection Method- A Case Report
This paper deals with the examination of genuine and disputed beedi (cheap cigarette wrapped in leaves) packages to establish genuineness. In one case, a dishonest trader made fake beedi , imitating the genuine product f...
International SIDS Data is Misleading and Should Not Be Used
The fields of medicine, scientific research, and forensic investigations are all dependent on informational data to make advancements. The accuracy of that information has a significant impact on the degree of progressio...
Mechanism and Treatment of Genital Injuries in Pediatric and Adolescent Girls: Data from Two Regional Centers in Turkey
Background/purpose: The aim of this study is to evaluate and compare the etiology, classification and treatment of genital injuries in pediatric and adolescent age group girls. Material and Method: Pediatric and adolesc...
Identification of Causation between Misdiagnosis and Death by the “Loss of Chance” Theory: Two Case Reports
Case 1: A 62-year-old patient was admitted to a provincial hospital for dull epigastric pain and was diagnosed with chronic atrophic cholecystitis, turgid type of gallstone and suspected gallbladder lesion. Two days late...