Genetic Polymorphism of Toll-Like Receptor 4 ASP299GLY Gene Polymorphism in Children with Helicobacter pylori Infection
Journal Title: Здоров`я дитини - Year 2013, Vol 6, Issue 49
Abstract
The objective of the study was to determine the characteristics of H.pylori infection in children with Toll-like receptor 4 (TLR4) ASP299GLY gene polymorphism. Methods. 31 children aged 9 to 17 years with chronic gastroduodenal pathology were observed. The control group included 95 healthy individuals. Results. Among children with chronic gastroduodenal pathology, 16.13 % had heterozygous genotype Asp/Gly, which is higher than in the control group (P = 0.01). It was shown that in H.pylori positive children the frequency of the heterozygous genotype Asp/Gly was higher than in H. pylori negative patients (17.4 and 12.5 %, respectively, OR = 1.48; P = 0.75). Among H.pylori positive children heterozygous genotype Asp/Gly was detected more frequently in children infected with СagA-positive strains of H.pylori, compared to patients with СagA-negative status (P > 0.5). It is proved that in children with TLR4 ASP299GLY gene polymorphism a decrease in the expression of TLR4 in biopsy sample of the gastric mucosa and water-soluble sCD14 levels was observed, together with prominent inflammatory mucosal changes (Pu < 0.05). Conclusion. Among children with chronic inflammatory gastroduodenal diseases, genotype Asp/Gly SNP Asp299Gly of the gene TLR4 is observed significantly higher than in healthy population. Presence of genotype Asp/Gly in children predisposes to contamination with H.pylori.
Authors and Affiliations
O. Ye. Abaturov, O. M. Gerasymenko, O. A. Shlykova, I. P. Kaidashev
Keywords
Related Articles
- EP ID EP236369
- DOI -
- Views 57
- Downloads 0
Ultrasound and Biochemical Indices of Endothelial Dysfunction at Hemorrhagic Vasculitis in Children
60 children with hemorrhagic vasculitis were examined in order to detect ultrasound and biochemical markers of endothelial dysfunction, depending on the degree of activity and the form. Serum monocyte chemoattractant pr...
Lyme disease. Pediatric Aspects (II Part)
Up to 25 % of all patients with Lyme borreliosis — children aged 5–9 years. In children also have three clinical and pathogenetic stages of Lyme disease. Typical sign of borreliosis — erythema ≥ 5 cm in diameter, develop...
Predictors of Hearing Loss in Premature Newborns
One of the most important problems of the perinatal period in premature infants is hearing disorder. Hearing test was performed in 1537 preterm infants with a gestational age of 22 to 36 weeks, they underwent medical tre...
Sanatorium-Resort Therapy Potential in the Treatment of Patients with Different Stages of Chronic Kidney Disease
Sanatorium rehabilitation measures aimed at preventing the development and progression of chronic renal failure on the early stages of chronic kidney disease also aimed at decrease in risk of complications development, i...
Case of Infective Endocarditis in a Child with Multiple Congenital Abnormalities: Clinical-Echocardiographic and Pathomorphological Analysis
The article presents a case of infective endocarditis, developed in the postoperative period in a child aged 1 year 10 months with Down syndrome, multiple congenital malformations of the heart and gastrointestinal tract....