Genetic polymorphism of vitamin D receptor determines its metabolism and efficiency
Journal Title: Біль. Суглоби. Хребет - Year 2017, Vol 7, Issue 2
Abstract
The review represents the results of researches of vitamin D receptor characteristics and its genetic polymorphism, which is variable in different populations, and also depends on age and gender. This polymorphism determines the association of vitamin D different concentration with the probability of bronchial asthma or chronic obstructive pulmonary disease development, and therefore the different efficacy of drug correction of vitamin D deficiency. However, the scientific data are contradictory, the molecular mechanisms of connection between vitamin D and bronchial tonus or allergic reactions remain unclear, which emphasizes the importance of studies to clarify the role of vitamin D in inflammatory, immune disorders in bronchial obstructive syndrome.
Authors and Affiliations
O. A. Yakovleva, O. M. Nikolova, I. A. Doroshkevych, N. V. Shcherbeniuk
Keywords
Related Articles
- EP ID EP218240
- DOI 10.22141/2224-1507.7.2.2017.108699
- Views 105
- Downloads 0
Age and Sex Features of Proximal Hip Geometry in Patients with its Intraarticular Fractures
According to the literature data, some parameters of the femoral bone (FB), namely the length of its axis, head-collum-diaphyseal angle, etc., are independent predictors of proximal femoral (PF) fractures, but such studi...
Impact of additional cholecalciferol supplementation on the level of thyroid peroxidase antibodies in patients with primary hypothyroidism
Background. The results of current numerous scientific researches testify to many-sided influence of vitamin D on different organs and systems of human organism. Purpose of the study — to study the effects of the additio...
Cataract in Inflammatory Diseases of Joints
In rheumatoid, juvenile idiopathic, chlamydial reactive, psoriatic arthritis and ankylosing spondylitis, cataract is being diagnosed in 5, 15, 6, 17 and 9 % of cases, respectively; its incidence, severity, and the maturi...
III International Symposium “Diseases of the bones and joints and the age” (March 12–14, 2018, Lviv, Ukraine)
.
Features of Pain Syndrome and Psychoemotional State in Patients with Psoriatic Arthritis Depending on Whether They Have Symptoms of Autonomic Dysfunction
According to the study results, patients with psoriatic arthritis, who have signs of autonomic nervous system dysfunction, are characterized by a higher intensity of pain syndrome manifestations (both due to sensory and...