Genetic resistance to HIV infection
Journal Title: Postępy Nauk Medycznych - Year 2010, Vol 23, Issue 10
Abstract
Variants conferring genetic resistance to HIV infection are observed within the HLA system, chemokine and cytokine receptor genes but also their ligands. Genetic variants of chemokine receptors play a role in modification of the HIV coreceptor availability on the cellular surface and thus influence susceptibility to infection and its progression. Additionally infection pace is related to the ligand expression – therefore regulatory variants in this system might result in overproduction of chemokines, coreceptor internalization and competitive inhibition of viral entry into the cell ( RANTES, SDF, IL4i IL10 polymorphisms). All above mentioned factors influence HIV progression and interplay in the multilayer system described in this review study.
Authors and Affiliations
Miłosz Parczewski
Keywords
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