Genetics : An Insight to Periodontal Disease
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 9
Abstract
Periodontal disease is a complex infectious disease resulting from interplay of bacterial infection and host response to bacterial challenge, and the disease is modified by environmental, acquired risk factors and genetic susceptibility. Molecular and Epidemiological studies of the oral microbial flora suggest that, microbial factors responsible for periodontal disease, alone cannot predict the presence or severity of the disease. Therefore, in high-risk patient groups, host susceptibility factors might play an important role in the etiology and progression of periodontal disease. Recently, host susceptibility factors, such as immune response factors, systemic disease state, and other environmental factors like smoking, have been found to be important contributors to the periodontal disease. Hence, periodontitis as a whole may represent a lifelong account of complex interactions between our genetic, our behavioral, and our environmental factors. This article, provides an overview of the most relevant literature, presenting the main concepts and insights of the strategies that have been emerging to better diagnose and treat periodontal disease based on biomarker analysis and host modulation.
Authors and Affiliations
Dr. Bushra . K Quazi, Dr. M. L. Bhongade, Dr Pranav S Patil, Dr Priti Charde
Keywords
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