GENETICS IN SOLVING DYSLEXIA PUZZLES
Journal Title: Acta Neuropsychologica - Year 2010, Vol 8, Issue 4
Abstract
Developmental dyslexia, or specific learning difficulties, is the most common neurobehavioral disorder affecting school-aged children, with a prevalence rate of 5-17.5%. Family and twin studies have pointed to a genetic component in the etiology of dyslexia. However, dyslexia is a complex disorder at both the genetic and environmental levels, and its nature so far remains unclear. Dyslexia is thought to be a ”complex trait” determined by a number of genes, each with small to moderate effects on the specific phenotype, involving various factors such as heterogeneity, incomplete penetrance, phenocopy, or oligogenic inheritance. Based on combined linkage and association analyses using both qualitative and quantitative phenotypes, multiple regions (DYX1-DYX9) on chromosomes 1, 2, 3, 6, 11, 13, 15 and 18 have been reported likely to contain genes contributing to dyslexia. Most recently four candidate genes (DYX1C1, KIAA0319, DCDC2, ROBO1) have been identified as associated with dyslexia. In this review, we focus on the genetic basis of dyslexia and provide an overview of several of the most susceptible loci on chromosomes and prominent candidate genes currently suspected of conditioning dyslexia.
Authors and Affiliations
Anna Wysocka, Małgorzata Lipowska, Adrianna Kilikowska
Keywords
Related Articles
- EP ID EP55354
- DOI -
- Views 101
- Downloads 0
BADS-C Instrument: An Ecological Perspective of the Executive Functions in Children with Attention Deficit Hyperactivity Disorder
Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is nowadays one of the most studied neurobehavioral disturbance. This pathology affects about 5.3% of children worldwide, while there has been registered a sign...
IMPACT OF CHEMOTHERAPY ON MEMORY, ATTENTION AND EXECUTIVE FUNCTIONS DEPENDING ON THE STAGES OF TREATMENT AND THE LEVEL OF DEPRESSION IN FEMALE PATIENTS WITH CANCER
Background: This study examined the neuropsychological effects of che motherapy on female cancer patients’ cognitive processes, depending on their stages of cancer treatment and mood (level of depression). Material/Meth...
DYSLEXIA RESEARCH AT THE TURN OF THE 21ST CENTURY: BEHAVIOURAL, NEUROIMAGING AND GENETIC FINDINGS
Behavioural studies have shown that dyslexics are a heterogeneous population and between-group comparisons are thus inadequate. Some subjects do not develop dyslexia despite having a deficit implicated in this disorder,...
NEUROPSYCHOLOGY OF PALINOPSIC HALLUCINATIONS
Background. The continued visual appearance of an object after its removal, for either an intermitten or noticeably sustained period of time, is known as palinopsia. Two types of palinopsic hallucinations are identified:...
EXPECTATIONS OF THE PATIENTS REFERRED TO PHYSICAL AND REHABILITATION MEDICINE DOCTORS
[b]Background: [/b]Understanding the expectations of patients seems to be an essential complement to medical diagnosis and an aid in ordaining the healing process. The aim of this study was to assess and analyse the expe...