Genexpert® MTB/RIF for Rapid Identification of Clinically Suspected MDR-TB Cases
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 3
Abstract
Introduction: An alarming increase in global incidence of drug-resistant Mycobacterium tuberculosis infection has created a critical need for methods that can rapidly detect it. Multidrug-resistant tuberculosis is defined as tuberculosis caused by M. tuberculosis that are resistant to at least isoniazid and rifampicin (RIF). The process to detect M. tuberculosis is time consuming. GeneXpert® MTB/RIF detects it within two hours. Aim and Objectives: The study was undertaken to detect M. tuberculosis and simultaneously RIF resistance in clinically suspected MDR cases of pulmonary TB by using GeneXpert® MTB/RIF. Compare MTB detection with sputum smear status and geographical mapping of clinically suspected MDR-TB cases and confirmed by GeneXpert® MTB/RIF. Material & Methods: Sputum samples from 100 clinically suspected MDR-TB cases were subjected to sputum smear microscopy followed by to GeneXpert® MTB/RIF. Results: Amongst 100 clinically suspected MDR-TB cases, 81 (81%) were smear-positive and 19 (19%) smear-negative. M. tuberculosis was detected amongst 69 (85.19%) smear-positive and 6 (35.29%) smear-negative cases. Amongst 75 MTB detected cases, 58 (77.33%) were RIF sensitive, 12 (16%) resistant and 5 (6.67%) indeterminate. Discussion: In100 clinically suspected MDR-TB cases, only 12 (16%) showed RIF resistance. The MDR-TB appears to be low in our area against clinically suspected MDR cases. This may be due to irregular, inadequate and intermittent treatment leading to clinical failure of primary line anti-TB drugs. Emphasis on proper counselling is needed while starting primary line anti-TB drugs. Conclusion: GeneXpert®MTB/RIF assay may prove to be useful in rapid diagnosis and initial management of clinically suspected MDR-TB cases.
Authors and Affiliations
Shevade Smita Uday
Keywords
Related Articles
- EP ID EP210982
- DOI -
- Views 60
- Downloads 0
To study the Effect of Duration of Smoking on Lipid Parameters in Otherwise Healthy Subjects
Background: India is one of the largest consumers of tobacco worldwide. Addiction of tobacco smoking is related with many health hazards. Nicotine of tobacco can be attributed to changes in lipid profile and its atheroge...
Comparative Analysis of Phacoemulsification Cataract Surgery with Rigid and Foldable IOLS in Terms of Safety, Efficacy and final Visual outcome – A Retrospective Study at a State Hospital
Objectives: The main purpose of the study was to make a comparative analysis of phacoemulsification cataract surgery with rigid and foldable IOLs in terms of safety, efficacy and final visual outcome. Material and Method...
Primary Hypothyroidism with Precocious Puberty and Pituitary Hyperplasia
Hypothyroidism is generally associated with delayed puberty. However it may sometimes present with incomplete precocious puberty. Also hypothyroidism may lead to pituitary hyperplasia as a feedback tumour. We present a c...
Forgotten Art of Communication: Has Doctor-Patient Communication taken a Back Seat in Modern Day Medical Practice?
A good communication skill for a doctor is central to the profession of medicine. The well established fact is that hospital staff –patient communication starts immediately on arrival of patient to hospital till his disc...
To study knowledge, attitude and actual practices regarding Mahatma Jyotiba Phule Jan Arogya Yojana at tertiary care hospital of MaharashtraA cross sectional study
MJPJAY is a state sponsored publically funded health insurance scheme (PFHI) launched by Govt. of Maharashtra. It provides free quality critical care for low income families. At tertiary care hospital, specialist is the...