Genexpert® MTB/RIF for Rapid Identification of Clinically Suspected MDR-TB Cases
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 3
Abstract
Introduction: An alarming increase in global incidence of drug-resistant Mycobacterium tuberculosis infection has created a critical need for methods that can rapidly detect it. Multidrug-resistant tuberculosis is defined as tuberculosis caused by M. tuberculosis that are resistant to at least isoniazid and rifampicin (RIF). The process to detect M. tuberculosis is time consuming. GeneXpert® MTB/RIF detects it within two hours. Aim and Objectives: The study was undertaken to detect M. tuberculosis and simultaneously RIF resistance in clinically suspected MDR cases of pulmonary TB by using GeneXpert® MTB/RIF. Compare MTB detection with sputum smear status and geographical mapping of clinically suspected MDR-TB cases and confirmed by GeneXpert® MTB/RIF. Material & Methods: Sputum samples from 100 clinically suspected MDR-TB cases were subjected to sputum smear microscopy followed by to GeneXpert® MTB/RIF. Results: Amongst 100 clinically suspected MDR-TB cases, 81 (81%) were smear-positive and 19 (19%) smear-negative. M. tuberculosis was detected amongst 69 (85.19%) smear-positive and 6 (35.29%) smear-negative cases. Amongst 75 MTB detected cases, 58 (77.33%) were RIF sensitive, 12 (16%) resistant and 5 (6.67%) indeterminate. Discussion: In100 clinically suspected MDR-TB cases, only 12 (16%) showed RIF resistance. The MDR-TB appears to be low in our area against clinically suspected MDR cases. This may be due to irregular, inadequate and intermittent treatment leading to clinical failure of primary line anti-TB drugs. Emphasis on proper counselling is needed while starting primary line anti-TB drugs. Conclusion: GeneXpert®MTB/RIF assay may prove to be useful in rapid diagnosis and initial management of clinically suspected MDR-TB cases.
Authors and Affiliations
Shevade Smita Uday
Keywords
Related Articles
- EP ID EP210982
- DOI -
- Views 50
- Downloads 0
A Case of Mixed Connective Tissue Disease Presenting with Recurrent Infections
Mixed connective tissue disease (MCTD) is a systemic inflammatory disease affecting connective tissue with the underlying autoimmunological mechanism. The core of MCTD is an appearance of symptoms of several other inflam...
A Study on Congenital Anomalies in Fetuses based on Educational and Socio-Economic Status of the Mother
Aims and Objectives: To assess the association of the various congenital malformations based on maternal education and socio-economic status. Materials and Methods: Fetuses of pregnant women attending government hospital...
Estimation of Muscle Strength in Women During the Different Phases of Menstrual Cycle
In women, the menstrual cycle is associated with fluctuations in female sex hormones through thenormal 28-30 days cycle.There is a strong link between these fluctuating levels of hormones and their influence on muscle pe...
Cytopathological Profile of Non Thyroid Neck Swellings – A Tertiary Centre Experience
Background: Neck masses form a relatively common presentation in an Surgical outpatient clinic. In the adult population a neck mass greater than 2 cm in diameter is reported to have greater than 80% probability of being...
A Clinical Study on Ocular Manifestations of Leprosy
From september 2012 to october 2013, during this period we have selected 100 leprosy patients as a sample for study of ocular manifestions of leprosy. There people were living in leprosy colonies in kurnool,others were a...