Genomic Modification by Ocimum canum Against Lead-Induced Chromosome Aberration and It’s Effect on Antioxidant Enzymes
Journal Title: Journal of Advanced Research in Medical Science & Technology - Year 2017, Vol 4, Issue 3
Abstract
Introduction: Anticlastogenic potential of Ocimum canum (Black leaf) extract was studied in bone marrow cells of mice using micronucleus assay. Experimental: 200mg/kg of Ocimum canum aqueous extract was administered as dietary supplement for 30-days. The mice were divided into three groups A, B and C. Animals in group A were fed with distilled water, B were treated with 2.5mg/kg lead acetate while group C were fed with 200mg/kg Ocimum canum aqueous extract and 2.5mg/kg lead acetate simultaneously. After 30-days, mice were sacrificed and chromosome preparations were made from bone marrow according to colchicines hypotonic-fixation air drying Giemsa schedule. The cytogenic end-point observed was chromosomal aberration which increased significantly (P<0.05) in group B animals treated with lead acetate only. However, the chromosomal aberration was significantly (P<0.05) reduced by the extract fed to animals in group C. In addition, the effect of the extract on the defensive antioxidant enzymes of the test animals was also assessed. Result: The results indicate synergistic effect of the extract on the antioxidant enzymes in the liver tissues. Conclusion: Hence, the results of this study suggest viable anticlastogenic and antioxidant potentials of Ocimum canum extract which could protect against lead-induced chromosomal aberration and as well enhance activities of antioxidant enzymes.
Authors and Affiliations
Dr. TugboboOladimeji Samuel,
Keywords
Related Articles
- EP ID EP268115
- DOI 10.24321/2394.6539.201705
- Views 106
- Downloads 0
Role of Chemical Entities in Ototoxicity
A large number of medications have been identified as toxic to the ears. These adverse drug reactions vary from minor, reversible effects to serious, permanent impairment of hearing. Toxic effects on the structures of th...
Use of Technology in Segregating Occupational Risks of Migrant and linking them with Services: Experiences from National AIDS Control Program for Migrants
Background: The migrant intervention in India was initiated during the National AIDS Control Program (NACP) Phase-2 (2002-2007). Even by the end of NACP Phase-3 (2010-11); the service uptake among migrants remained very...
Pathways to Control Health Diseases through Remediation of Environmental Pollution
In the era of environment, the main cause of health deterioration in the present generation is mainly due to environmental pollution as the air we breathe, food we eat, water we drink and the place we live, all are pollu...
Inhibitory Effect of Lime on Arsenic-Induced Lipid Peroxidation in Growing Rice Plants
Seedlings of Ofada rice (Oryza sativum L.) were raised in sand (swampy) and clay (upland) cultures under 500 µM sodium arsenate and 500 µM Ca(OH)2 aqueous extract for 40 days. The uptake and distribution pattern of arsen...
Emerging Public Health Concern and Air Pollution: A Case Study of Delhi’s Air Pollution Governance
Air Pollution is a cause of concern in the present world as it is not responsible for only deteriorating our environment but is associated with severe health risks to the human life as well. With the increasing levels of...