Genotoxic Effect of Garlic Extract on Root Tips of Allium Cepa L
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 2
Abstract
The experiment was carried out to study the inhibition of the root growth and cytotoxic effects of garlic aqueous extract on onion bulbs (Allium cepa L.). The onion bulbs were treated with different concentrations of garlic aqueous extract (0, 5, 10, 15, 20 mg / l) for 72 hours in plastic laboratory tubes. The results indicated that the mitotic index and root growth rate of onion were considerably decreased in comparison to the control. We found that the cytotoxic effect of garlic extracts depends on the concentration and the exposure time. The EC50 value of garlic extract was 5 mg/l after 72 hours and the mitotic index value was (9%) at the same concentration (5 mg/l). The chromosomal aberrations were found to be increased as the concentration of the garlic extract increased when compared to control. The observed chromosomal abnormalities were chromosomal bridge, nuclear lesion, sticky chromosome and abnormal metaphase. We conclude that garlic extract have a genotoxic effect on the root tip cells of onion bulbs.
Authors and Affiliations
Essam A. A. Sadaqa1, Saeed S. Mohammed, Sameer H Qari2, Khaled S. Ali1
Keywords
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