Analgesic, Antiinflammatory Activity of Tinospora Cordifolia (Guduchi) and Valeriana Wallichi (Tagara) In Albino Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 2
Abstract
Objectives: The present study was carried out 1) To evaluate analgesic and anti-inflammatory activity of T.Cordifolia and V.Wallichi in albino rats. 2) To compare the analgesic and anti-inflammatory activity of T.cordifolia and V.wallachi with standard drugs pentazocine & diclofenac sodium respectively. Methods: Analgesic activity of marketed preparation of T.cordifolia, V.wallachi (Guduchi, Tagara from Himalaya Herbal products) was evaluated by tail flick method using analgesiometer. Antiinflammatory activity was studied by rat paw edema method, using plethysmograph. Male wistar albino rats weighing 200 -250g are divided into 8 groups with each group containing six rats (n=6). Test drugs (100mg/kg of T.cordifolia + 120mg/kg of V.wallachi) were administered orally & standard drugs pentazocine 2mg/kg & diclofenac sodium 20mg/kg were given intraperitonally. One way ANOVA was used for statistical calculation at 5% significance level. Results: Both test drugs have shown significant analgesic activity (P<0.05), 100mg of T.cordifolia demonstrated significantly higher effect than V.wallachi. And both test drugs has significant anti-inflammatory activity, which was identical. Conclusion: Tinospora cordifolia & Valeriana wallachi showed significant analgesic and anti-inflammatory activity.
Authors and Affiliations
M. K. Drishya1, S. Binu kumari, M. Mohan kumar, A. P. Ambikadevi4, B. Aswin 5
Keywords
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