GIST: A Study of Diagnostic and Predictive Factors in Reference to the Site

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GIST: A Study of Diagnostic and Predictive Factors in Reference to the Site

Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 2

Abstract

Gastrointestinal stromal tumors (GIST) are biologically distinctive stromal tumor and are the most common mesenchymal tumor of gastrointestinal tract but many times creates great clinical confusion due to its vivid clinical presentation, location and histology. Immunohistochemistry plays a great deciding role even in the era of molecular biology as around 90% GISTs are CD117 positive which represents the presence of KIT receptor (i.e. a 145-kDa glycoprotein) & is responsible for uncontrolled cell proliferation. Hence targeted therapy can be planned for all those cases with good clinical outcomes. In the present study, we have considered various aspects of GIST including their size, histomorphological and immunohistochemical characteristics with their relevance in diagnosis and as predictive factor for risk management.

Authors and Affiliations

Kalpana Mangal, Alka Mittal, Aditi Jain, Jayanti Mehta

Keywords

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EP ID EP537707
DOI 10.21276/ijmrp.2018.4.2.004
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