Glycosylated Hemoglobin Level and its Correlation with Pulmonary Function Test in Type II Diabetics

Journal Title: Scholars Academic Journal of Biosciences - Year 2014, Vol 2, Issue 8

Abstract

The risk of development and progression of chronic complications of diabetes is closely related to the degree of glycemic control as measured by glycosylated hemoglobin level. Glycosylation of tissue proteins occur when blood glucose level remain elevated for a prolonged duration. Due to this, there occur irreversible changes in the chemical structure of tissue proteins. Connective tissues in skin, muscles, respiratory system, vascular bed, kidney, peripheral nervous system, etc. are the major targets for glycosylation. Diabetic patients show reduced pulmonary function tests. Present study was undertaken to find out the correlation between glycosylated hemoglobin and pulmonary function test in type II diabetics. 42 Type II diabetics and 40 normal subjects were selected for the study. Anthropometric parameters, blood investigations and P.F.T. was performed on all subjects. Fasting and Post Meal blood glucose levels as well as HbA1c % were significantly higher in Type II diabetics as compared to controls. All P.F.T. parameters excepting FEV1 % were significantly reduced in Type II diabetics. A significant correlation was found between HbA1c % and various P.F.T parameters like FVC, FEV1, FEF25 – 75%, FEF0.2 – 1.2L, PEFR and MVV. Also a negative correlation was found between HbA1c % and all P.F.T parameters except FEF25 – 75 %, and MVV. Decreased values of P.F.T parameters in Type II diabetics can be attributed to increased glycosylation of connective tissues and other proteins that leads to decrease in elasticity, flexibility, recoil, etc. of connective tissues producing stiff tissue and ultimately leading to a stiff lung i.e. restrictive lung pathology.

Authors and Affiliations

Gajbhiye RN, Tambe AS

Keywords

Related Articles

A new spontaneous tetraploid inter-specific hybrid in coffee (Coffea sp.)

A new inter-specific natural hybrid was spotted in a private coffee plantation in Coorg District of Karnataka during the year 1998. The hybrid was observed to be a natural hybrid of a diploid tree coffee (Coffea excelsa)...

Comparative potency of three insecticides against the infestation of brinjal shoot and fruit borer, Leucinodes orbonalis Guen.

Abstract: Brinjal shoot and fruit borer (BSFB), Leucinodes orbonalis Guenee, is a serious pest of brinjal or eggplant (Solanum melongena L.). Due to increasing levels of resistance of L. orbonalis to different insecticid...

Microalgae as Sustainable Renewable Energy feedstock for bioethanol production

Due to rapid growth in population and industrialization, worldwide ethanol demand is increasing continuously. Microalgae have shorter growth cycle as compared to other plant; hence the algae are a verypromising source of...

Comparative Effects of Ficus Exasperata Vahl. Aqueous Leaf Extract and Hydrochlorothiazide on Urinary Excretions in Normotensive Rats

The allegations related to the antihypertensive effect of Ficus exasperata in the treatment of hypertension were identified. This increases its use in primary health care for many people and can cause disturbances in the...

Efficacy of MR Imaging in Detection of Early Vertebral Metastasis Versus Radionuclide Bone Scan

Skeletal metastases occur with many malignancies, but they are most common in carcinomas of the breast (47-85%), prostrate (54-85%), lung (32%), kidney (33-40%), and thyroid (28-60%). Most bone metastases are hematogenou...

Download PDF file
  • EP ID EP377975
  • DOI -
  • Views 79
  • Downloads 0

How To Cite

Gajbhiye RN, Tambe AS (2014). Glycosylated Hemoglobin Level and its Correlation with Pulmonary Function Test in Type II Diabetics. Scholars Academic Journal of Biosciences, 2(8), 556-560. https://europub.co.uk/articles/-A-377975