Glycosylation of the Pyrrolopyrimdine and Its Cyclisation into Tricyclic Nucleoside for Incorporation into Synthetic DNA
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 11
Abstract
Alkylation of DNA is commonly used during cancer chemotherapy. The most common chemotherapeutic agents are those that alkylate the O 6 -position of guanine. Attempts were made in the modification of the O6-position of guanine for recognition by methylguaninemethyltranferase (MGMT) enzyme for DNA cross linking studies in an attempt to search for new cancer chemotherapeutic agents. Glycosylation of the pyrrlopyrimidine (modified guanine) was carried out successfully with 1-Chloro-2’-deoxy-3,5-di-O-ptoluoyl--D-erythro-pentofuranose to give the desired nucleoside. Several attempts were made inorder to cyclise the different modified nucleosides into their respective tricyclic nucleosides all of which were found to be unsuccessiful. However, this was found to be possible only with bischlorinated nucleoside using NaOH which give a fluorescence tricyclic nucleoside and the chemistry was presented here.
Authors and Affiliations
Kabir Abdu
Keywords
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- EP ID EP422635
- DOI 10.9790/5736-1111016170.
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