Down to atomic-scale intracellular water dynamics

Water constitutes the intracellular matrix in which biological molecules interact. Understanding its dynamic state is a main scientific challenge, which continues to provoke controversy after more than 50 years of study....

Have we become overly reliant on lipid rafts? Talking Point on the involvement of lipid rafts in T-cell activation

During the past decade, the lipid-raft hypothesis has focused attention on the role of membrane domains in controlling cellular functions. Among the best-studied roles of lipid rafts is the regulation of T-cell signallin...

Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates

Atrophin family proteins, including the vertebrate arginine–glutamic acid dipeptide repeats protein (RERE) and Drosophila Atrophin (Atro), constitute a new class of nuclear receptor corepressors. Both RERE and At...

Natural solutions to climate change. Greenhouse gases, high-energy crops and the future of the world

T-cell antigen receptor triggering and lipid rafts: a matter of space and time scales. Talking Point on the involvement of lipid rafts in T-cell activation

T-cell antigen receptor triggering mechanisms and lipid rafts are of broad interest, but are also controversial topics. Here, we review some recent progress in these two research fields, which has been accomplished mostl...