Gorlin Goltz Syndrome – Case Series and Review of Literature.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 4
Abstract
The Gorlin-Goltz syndrome, also known as nevoid basal cell carcinoma syndrome (NBCCS), is an infrequent multisystemic disease inherited in a dominant autosomal way, which shows a high level of penetrance and variable expressiveness It is characterized by disorders affecting multiple systems including skeletal, cutaneous, ophthalmic, reproductive, and nervous systems.. Gorlin syndrome is associated with germlinemutations in components of the Sonic Hedgehog pathway, including Patched1 (PTCH1) and Suppressor of fused (SUFU). The purpose of this present article is to describe the clinical, radiological, and histopathological findings in three cases of Gorlin Goltz syndrome diagnosed in our department, and to discuss the role of gene mutation analysis and circumstances to avoid in order to prevent primary manifestations.
Authors and Affiliations
Dr. Arun Devaraj, Dr. Sudha . S, Dr. Sujatha Varma, Dr. Navajeevraj MN, Dr. Suchithra KS
Keywords
Related Articles
- EP ID EP574616
- DOI 10.9790/0853-1804147686.
- Views 55
- Downloads 0
KAP of Antibiotic Resistance among the Junior Doctors in RIMS
Introduction: WHO Defines The Appropriate Use Of Antimicrobials As “The Cost Effective Use Of Antimicrobials Which Maximizes Clinical Therapeutic Effect While Minimizing Both Drug-Related Toxicity And The Development Of...
“Determination of potential virulence factors in clinical isolates of various Candida species to assess its clinical implication in a tertiary care hospital in Eastern India”.
Candidiasis is the commonest fungal disease in human caused by various species of the yeast like fungi belonging to the genus Candida. It is commonly encountered as an endogenous infection due to its commensal nature. Tr...
Type IV Renal tubular acidosis – Pseudohypoaldosteronism
.
Health Technology Assessment – A Road To Better Healthcare System In India
Abstract: Health technology assessment (HTA) refers to the systematic evaluation of properties, effects, and/or impacts of health technology. It is a multidisciplinary process to evaluate the social, economic, organizati...
A Comparative Microleakage Analysis of a Newer Restorative Material – An Exvivo Study
Aim: To Compare and evaluate the microleakge of a newly introduced restorative material, Cention N, with the commonly used posterior restorative materials.MATERIALS AND METHODS:50 single rooted premolars free of caries o...