Green and efficient synthesis of functionalized 3-amino-2-oxofuranes using trityl chloride
Journal Title: Iranian Chemical Communication - Year 2017, Vol 5, Issue 4
Abstract
Extremely facile and efficient procedure has been developed for the synthesis of alkyl 2,5-dihydro-2-oxo-5-aryl-3-(arylamino) furan-4-carboxylate in the presence of trityl chloride (TrCl) as an organic catalyst in ethanol at ambient temperature. One-pot three-component reaction of aromatic amines, dimethyl and/or diethyl acetylenedicarboxylates and aryl aldehydes offorded the corossponding 3-amino-2-oxofurane derivatives in good to high yields. The presented method offers several advantages such as green and mild conditions, simplicity of operation, non-toxicity of the catalyst and high atom economy. Moreover, the products were obtained through simple filtering and no need to column chromatography, which reduces the waste as well as environmental pollutions.
Authors and Affiliations
Seyed Sajad Sajadikhah, Mahboubeh Zarei
Keywords
Related Articles
- EP ID EP260524
- DOI -
- Views 115
- Downloads 0
The green synthesis of pyrano[3,2-c]quinoline-2,5-dione derivatives catalyzed by acidic ionic liquid under ultrasound irradiation
Abstract-A novel and efficient method has been developed for the synthesis of pyrano[3,2-c]quinoline-2,5-dione derivatives by the convenient ultrasound-mediated condensation of 4-hydroxyquinolin-2-one with Meldrum’s acid...
Application of carbon ceramic modified electrode with prussian blue for electrocatalytic oxidation of nitrite ion
A novel chemically modified electrode containing Prussian blue complex was achieved on the surface of glass carbon electrode by sol-gel technique. The electrochemical behavior of modified electrode was characterized by c...
Isolation and identification of gallic acid from the elaeagnus angustifolia leaves and determination of total phenolic, flavonoids contents and investigation of antioxidant activity
Elaeagnus angustifolia has many potential applications in drugs, detergents, perfumes, herbal teas and show various biological and pharmacological activities, such as anti-inflammatory, antipyretic and other effective tr...
LaCl3.7H20: An efficient catalyst for one-pot multi-component synthesis of 1,4-polyhydroquinoline derivatives through unsymmetrical Hantzsch reaction
An efficient one pot multi component synthesis of 1, 4-Polyhydroquinoline derivatives through unsymmetrical Hantzsch reaction using lanthanum chloride heptahydrate (LaCl3.7H2O) from an aromatic aldehyde, ethyl acetoaceta...
Isoquinoline Promoted Synthesis of alkyl 2-(1-alkyl-5-oxo-3-phenyl-2-thioxotetrahydro-4H-imidazol-4-yliden) acetate derivatives
Derivatives of thiazolidinone ring systems are known to act as anti-HIV infections , analgesic, anti-bacterial, anti-convulsant, anti parasitic, potential anti-inflammatory and herbicidal agents. Due biological activitie...