Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 6
Abstract
DNA-damaging compounds (e.g., alkylating agents, cytotoxic antibiotics and DNA topoisomerase poisons) are themost widely used anticancer drugs. The inability of tumor cells to properly repair some types of DNA damage may explain why specific DNA-damaging drugs can selectively kill tumor cells. Phenylglyoxal is a dicarbonyl compound known to react with guanidine groups such as that of the DNA base guanine, therefore suggesting that phenylglyoxal could induce DNA damage and have anticancer activity.
Authors and Affiliations
José Calderón-Montaño, Estefanía Burgos-Morón, Manuel Orta, Nuria Pastor, Concepción Perez-Guerrero, Caroline Austin, Santiago Mateos, Miguel López-Lázaro
Keywords
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