Haemato-biochemical, radiographic and clinical outcome in healing of femoral fracture with retrograde intramedullary pin in conjunction with demineralized bone matrix in dogs
Journal Title: Journal of Experimental Biology and Agricultural Sciences - Year 2017, Vol 5, Issue 0
Abstract
The study was undertaken to evaluate the haemato-biochemical, radiographic and clinical outcome of femoral fracture healing in dogs. The dogs were treated with open reduction and internal fixation (ORIF) with retrograde intramedullary pin with or without full circlage wire (Group I) and ORIF with retrograde intramedullary pin with or without full circlage wire along with incorporation of demineralized bone matrix (Group II) at the fracture site. The haemato-biochemical, radiographic and clinical outcome assessment were done on 0, 21st, 45th and 60th day. The haemato-biochemical parameters studied were alkaline phosphatase, creatinine kinase, serum calcium, total erythrocyte count, total leucocyte count, haemoglobin, packed cell volume, lymphocyte, monocyte, thrombocyte, mean platelet volume, mean corpuscular volume and mean corpuscular haemoglobin. Modified Thomas splint was applied post operatively till 21st day; dogs started walking from 3rd day onwards. The haematological, radiographic and clinical outcome in the different time period and between the groups showed non-significant minor variation during the period of study. The biochemical activity of alkaline phosphatase was better in group II. On 60th day radiograph showed complete bridging of fracture end with callus in both the group except for one animal of group II. Based on better biochemical activity of alkaline phosphatase in group II and similar haematological, radiographic and clinical outcome it can be concluded that demineralized bone matrix can augment the healing of femoral fracture.
Authors and Affiliations
Singh C K, Sarma K K, Kalita D, Tamuly S, Hussain J, Deuri B , Nath P J
Keywords
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- EP ID EP428055
- DOI 10.18006/2017.5(2).201.207
- Views 60
- Downloads 0
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