HAEMATOLOGICAL AND KIDNEY FUNCTION MARKERS EVALUATION OF CRUDE OIL CONTAMINATED FEEDS SUPPLEMENTED WITH ANTIOXIDANTS IN ALBINO WISTAR RATS.
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 8
Abstract
This study investigated the ameliorative effect of antioxidant on crude oil contaminated feeds in wistar rats. Forty male albino rats were randomly assigned to five experimental groups of eight rats each namely; Control which was fed with normal feeds, crude oil control (negative control) which was fed with contaminated feeds, and the treatment groups which were fed with contaminated feed and treated with; 0.5mg of garlic and 1.7mg of Vitamin C and E respectively. After 7 and 14 days, body weights were taken and rats sacrifice under anesthesia. The hormonal level, kidney function enzymes and hematological indices were determined. It was observed that crude oil contamination significantly (p<0.05) reduced the body weight of the wistar rats, and the antioxidants improved it, although not significantly (p<0.05). The result also showed that crude oil significantly (p<0.05) reduced the testosterone and FSH level in the rats on day 7 and 14, which the antioxidants significantly improved (p<0.05). Anemia was also observed in rats fed with crude oil contaminated feeds which were also revived by antioxidants although not significant (p<0.05) improvement. The kidney function enzymes were also observed and there was a significant (p<0.05) increase in the blood urea nitrogen level and the creatinine level which further significantly increased (p<0.05) when treated with vitamins C and E. In conclusion, Antioxidants such as Vitamin C, E and Garlic improved body weight, reproductive hormones, hematological and Kidney function enzyme levels in male albino wistar rats fed with crude oil contaminated feeds.
Authors and Affiliations
Dr. Ukpanukpong R. U.
Keywords
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